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IJMPS - Vol 04 Issue 08, April, 2014

Pages: 01-09

ADVERSE EFFECTS OF ZIDOVUDINE ON RAT'S VISION: ANTIOXIDANT AND ENZYMOLOGY PERSPECTIVES

Author: Patrick Sunday Igbigbi, Josiah Obaghwarhievwo Adjene, Ezekiel Uba Nwose

Category: Healthcare

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Abstract:

Background: The biochemical effects of chronic administration of Zidovudine on intracranial auditory relay centre of adult Wistar rats has been studied and reported. The objective of this related study is to investigate how the oxidative stress and antioxidant enzymes biomarkers in the tissues of intracranial visual relay centre of zidovudine-treated group compare with non-treated group. Materials and Methods: As in the study on auditory functions, the rats of both sexes (N=40), with an average weight of 200g were randomly assigned into treatment (n1=20) and control (n2=20) groups. The rats in the treatment group received 300mg/70kg (0.857mg/200g) body weight of zidovudine being the dosages required twice daily dissolved in distilled water daily and given for thirty days through orogastric tube administration While the control rats received equal volume of distilled water through the same route and for the same period. Catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, lactate dehydrogenase and superoxide dismutase; as well as malondialdehyde were tested in the superior colliculus and lateral geniculate body tissues. Results: Malondialdehyde as a non-enzyme biomarker of oxidative stress as well as glutathione peroxidase and superoxide dismutase activities are higher on the treated superior colliculus, but lower in lateral geniculate body, with statistical significant (P<0.05) difference observed. Conclusion: The effects of zidovudine on antioxidant enzymes and oxidative stress in superior colliculus and lateral geniculate body of adult Wistar rats are discordant. Further studies are required to investigate whether enzymology and oxidative stress tests could be useful to ascertain zidovudine efficacy and toxicity on visual relay centers.

Keywords: lateral geniculate body, biochemical effects, superior colliculus, vision, Zidovudine

Citation:

Patrick Sunday Igbigbi, Josiah Obaghwarhievwo Adjene, Ezekiel Uba Nwose. ADVERSE EFFECTS OF ZIDOVUDINE ON RAT'S VISION: ANTIOXIDANT AND ENZYMOLOGY PERSPECTIVES . Int J Med Phar Sci. 2014 Vol 04 Issue 08, April, 01-09

Research Incentive Schemes

Awards, Research and Publication incentive Schemes by IJMPS

Best Article Award:

One article from every issue is selected for the ‘Best Article Award’. Authors of selected ‘Best Article’ are rewarded with a certificate. IJMPS Editorial Board members select one ‘Best Article’ from the published issue based on originality, novelty, social usefulness of the work. The corresponding author of selected ‘Best Article Award’ is communicated and information of award is displayed on IJCRR’s website. Drop a mail to editor.ijmps@gmail.com for more details.

Women Researcher Award:

This award is instituted to encourage women researchers to publish her work in IJMPS. Women researcher, who intends to publish her research work in IJMPS as the first author is eligible to apply for this award. Editorial Board members decide on the selection of women researchers based on the originality, novelty, and social contribution of the research work. The corresponding author of the selected manuscript is communicated and information is displayed on IJMPS’s website. Under this award selected women, the author is eligible for publication incentives. Drop a mail to editor.ijmps@gmail.com for more details.

Emerging Researcher Award:

‘Emerging Researcher Award’ is instituted to encourage student researchers to publish their work in IJMPS. Student researchers, who intend to publish their research or review work in IJMPS as the first author are eligible to apply for this award. Editorial Board members decide on the selection of student researchers for the said award based on originality, novelty, and social applicability of the research work. Under this award selected student researcher is eligible for publication incentives. Drop a mail to editor.ijmps@gmail.com for more details.

Best Article Award

A Study by Pandya S. et al. entitled "Acute and 28-Day Repeated Dose Subacute Toxicological Evaluation of Coroprotect Dry Syrup in Rodents" is awarded Best article for Vol 12 issue 05 of IJMPS

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