The present study examined the antioxidant effect of alcoholic extract of root and fruit of Solanum xanthocarpam and Picrorhiza kurroa rhizome at various concentrations. The results of the study revealed that in reducing power the highest activity was observed in S. xanthocarpam root followed by least with P. kurroa rhizome. In ABTS method, S. xanthocarpam root exhibited the highest activity with IC50 values 373.42 __ampersandsignmicro;g/ml followed by least P. kurroa rhizome with IC50 values 491 __ampersandsignmicro;g/ml. In DPPH scavenging activity P. kurroa rhizome showed highest scavenging activity with IC50 values 72.58 __ampersandsignmicro;g/ml followed by S. xanthocarpam root recorded the lowest scavenging activity with IC50 values 197.24 __ampersandsignmicro;g/ml. In superoxide anion radical scavenging activity, S. xanthocarpam fruit were found to be effective scavenging activity of 56% with IC50 values 392.16 __ampersandsignmicro;g/ml and least exhibited by S. xanthocarpam root scavenging of 50% with IC50 values 484.12 __ampersandsignmicro;g/ml and these are all compared with the standard BHA and BHT. The results has revealed that the plant extract has significant antioxidant activity and are encouraging for further assessment to elucidate the mechanism of action and to the antioxidant effect and the membrane stability.