Objective: To study the effect of Alpha-methyl-P-Tyrosine (AMT) pretreatment on Stereotyped Behaviour Induced by Caffeine (CAF), Apomorphine(APO), Dexamphetamine (DAM) in Rats. Materials and Methods: Albino rats of either sex (weighing 100-180 g) were used. Albino rats were used by random distribution in group of 10 animals each. Intensity of Stereotyped Behaviour (SB) is assessed by Costall and Naylor scoring system. All drug solutions were prepared immediately before use and were injected i.p. The volume of injection was 2 ml/kg body weight for caffeine and other remaining drugs. While it was 5 ml/kg body weight for alpha-methyl-p-tyrosine (AMT). Drug doses, routes of administration and the testing time intervals were selected based on previous studies conducted in our laboratory and those reported in literature. The results were expressed as mean __ampersandsignplusmn; S.E.M. and data was analysed by student__ampersandsignrsquo;s unpaired t-test with differences considered significant at P__ampersandsignlt;0.05. Result: Pretreatment with 100 mg/kg alpha-methyl-p-tyrosine (AMT) significantly antagonized the SB induced by 10, 20 and 40 mg/kg caffeine. Pretreatment with 200 mg/kg AMT abolished the SB induced by 10 and 20 mg/kg caffeine and significantly antagonized SB induced by 40 mg/kg caffeine. Pretreatment with 100 and 200mg/kg AMT did not significantly influence the intensity of SB induced by 1.5 and 3mg/kg apomorphine. Pretreatment with 100 and 200 mg/kg alpha-methyl-p-tyrosine significantly antagonized the SB induced by 5 and 10 mg/kg dexamphetamine