Background of Study: Malaria is the one of most common cause of fever and morbidity in the tropics and a significant source of mortality, especially among infants and young children (2). So its drug therapy needs to be review. Aim: Evaluate the use of antimalarial agents in treatment of patients admitted to KMC Hospital, Attavar (Mangalore) with a diagnosis of Malaria. Research Methodology: We analyzed the use of antimalarial agents in treatment of patients admitted to KMC Hospital, Attavar (Mangalore) with a diagnosis of Malaria and compared it with the guidelines on Diagnosis and Treatment of Malaria in India which were revised in 2007 by the Ministry of Health of India. A total sample size was 478 and pattern of Uncomplicated and complicated Malarial Parasite Infection was evaluated. Results: 26% of the admitted patients receive a combination of 3 anti-malarial agents, 58% received a combination of 2 antimalarial agents, while only 16% of the patients were managed with monotherapy as part of treatment. Lumefantrine was the most commonly prescribed agent in 86.5% of the patients, followed by Mefloquine 41.1%. Conclusion: There is an increased use of Artemisinin as first line drugs in Mangalore, irrespective of the causative agent for malaria, which is an unhealthy practice. The use of primaquine for all types of malaria is also on the increase and this practice must be curbed too.