Objectives: The aim of this study was to evaluate the secretory status of leptin, ghrelin, neuropeptide Y and galanin in simple obese subjects compared to normal weight subjects Material and Method: The study group consists of twenty subjects each of overweight (OW), obese (OB) and morbid obesity (MO) classified on the basis of body mass index (BMI) issued by Ministry of Health and Family Welfare, GOI for simple obesity. Thirteen subjects with BMI below 23kg/mt2 constituted the control group without any sign and symptom of diseases. Leptin, ghrelin, neuropeptide Y and galanin concentration were estimated by commercially available ELISA kit. Result: Serum leptin levels were significantly elevated in OW, OB and MO groups as compared to healthy non obese subjects. Mean neuropeptide Y and galanin levels were higher in OB and MO subjects as compared OW and normal weight subjects. While mean ghrelin levels were higher in normal weight and OB subjects as compared to OW and MO group. Except ghrelin, it was observed that with increasing BMI there was an increase in levels of leptin, neuropeptide Y and galanin which was also statistically significant (p value 0.7; p value __ampersandsignlt;0.001). Conclusion: As inappropriate levels of serum leptin, neuropeptide Y and galanin were observed with the change in BMI, they can serve as a reliable tool to monitor the obesity due to dietary habits and sedentary lifestyle.