Objective:1. To study the effect of Caffeine on dopaminergic system in rats and compare its intensity with effects produced by dexamphetamine and apomorphine. 2. To study the effect of pretreatment of haloperidol on SB induced by Caffeine, dexamphetamine and high doses of apomorphine. Materials and Methods: Albino rats of either sex (weighing 100-200 g) were used. Albino rats were used by random distribution in group of 10 animals each. Intensity of Stereotyped Behaviour(SB) and catalepsy is assessed by Costall and Naylor scoring system. All drug solutions were prepared immediately before use and were injected i.p. The volume of injection was 2 ml/kg body weight for caffeine and other remaining drugs. Dexamphetamine(DAM,) haloperidol, apomorphine were used. Drug doses, routes of administration and the testing time intervals were selected based on previous studies conducted in our laboratory and those reported in literature. The results were expressed as mean __ampersandsignplusmn; S.E.M. and data was analysed by student__ampersandsignrsquo;s unpaired t-test with differences considered significant at P__ampersandsignlt;0.05. Result: Pretreatment with postsynaptic striatal D2 and D1 DA receptor antagonist haloperidol (0.25mg/kg i.p.) abolished the SB induced by 10mg/kg i.p. caffeine and significantly antagonized the SB induced by 20 and 40mg/kg i.p.