Aim: Generic drug is defined as the pharmaceutical product which is usually intended to be interchangeable with an innovator product or the pharmaceutical product which is manufactured without a license from the innovator company.Americans save an estimated $8 billion to $10 billion at retail pharmacies by purchasing generic drugs rather than brand drugs. Indians are restricted for the further medical management due to monetary constrains because of excess out-of-pocket (OOP) expenses to medications. Methodology: An observational study was conducted at an Indian hospital in the outpatient department of Paediatrics to evaluate the excess expenditure of money on brand drugs. Prescriptions from a total of 255 patients were included in the study to compare the cost of brand drugs to that of generic drugs. Results: The total cost of brand drugs for 250 prescriptions was found to be Rs. 52158.03, whereas the estimated cost for generic drugs was just Rs. 24738.01. Discussion: The results obtained from the present study showed that more than 50% of money could have been saved if generic drugs were prescribed by the physicians instead of brand drugs. Conclusion: Patients should discuss the possible generic drug options with their doctor and/or pharmacist to reduce their burden in terms of monetary unit.