Background of study: Exposure to blood and body fluids is one of the most common and avoidable occupational hazards faced by health care providers (HCP). This study was carried among nursing students in a teaching hospital of Berhampur with the following objectives. Aim / Objective: i) To estimate the incidence of exposure of nursing students to blood and body fluid during the last one year ii) To identify practices and circumstances leading to needle stick injuries/cut/splash iii) To study the knowledge regarding health hazards following exposure and preventive measures involved in it Research Methodology: A cross-sectional anonymous study was carried out in the month of Oct 2010 using a semi-structured pre tested questionnaire as study instrument and data was analyzed manually using percentage and chi square test Results: The present study showed high incidence of occupational exposure among nursing students (37.4 %). Almost half of the exposures were due to splashing of body fluids/blood the rest was due to needle-stick and sharp injuries. Conclusion: There is a need to educate HCP regarding risk, prevention and management of occupational exposure.