The most common genetic disease in Pakistan is Thalassemia. The objective of this research was to find the relationship between Quality of Life and Coping Styles in Caregivers of Patients suffering from Thalassemia Major. The sample for the present study consisted of 202 (Men=102; Women=100) caregivers of patients suffering from thalassemia major. Data was collected from caregivers of patients suffering from thalassemia major from two different institutes i.e, Thalassemia center, Rawalpindi and Fatimid foundation, Lahore. Urdu versions of World Health Organization Quality of Life Scale-Brief and Brief Cope were used. Alpha coefficient reliabilities, Pearson Product Moment correlation and Independent sample t test were run to fulfill the objective of the study. Results revealed a significant positive relationship between problem focused coping, positive coping and psychological state among caregivers of patients suffering from thalassemia major. Moreover, caregivers of patients suffering from thalassemia major undergoing chelation therapy scored high on relationship to salient features of environment as compared to caregivers of patients suffering from thalassemia major undergoing blood transfusions. On the contrary, caregivers of patients suffering from thalassemia major undergoing blood transfusions exhibited frequent use of coping styles as compared to caregivers of patients suffering from thalassemia major undergoing chelation therapy.