Introduction: Cutaneous adverse drug reactions (cutaneous ADRs) are most common and occur in up to 8% of the global general population and in 2-3% of hospitalized patients. Hence, the present study was undertaken to determine the clinical pattern of all cutaneous ADRs. It also emphasises on the need and importance of an effective pharmacovigilance programme. Objective: To assess the clinical pattern of cutaneous ADRs and to recognize offending drug. Method: This study was conducted in a 800 beded tertiary care hospital in central India. All patients who attended dermatology OPD were screened and patients with suspected cutaneous ADRs presented primarily or referred from other departments of the hospital during the study period were enrolled. The diagnosis of the cutaneous ADR was based on history of drug ingestion, clinical findings and exclusion of other simillar disorders and it was done by a consultant dermatologist. Results: From 1st January 2011 to 31st December 2011, 116 cases of cutaneous ADRs (64 males and 52 females) were reported. Urticaria/angioedema (32.75%) was the most frequent cutaneous ADR reported followed by maculopapular rash (27.58%), fixed drug eruption (20.68%) and photosensitivity (12.06%). Antimicrobial drugs (40.51%) were the most common offending group of drugs causing the cutaneous ADRs followed by analgesic/anti-inflammatory/antipyretics (32.75%) and antiepileptics (14.65%). Sulfonamides were the most common offending drug followed by ibuprofen among all individual drugs. Conclusion: Urticaria/angioedema was the most common cutaneous ADR seen. Sulphonamides were the most common offending agent causing cutaneous ADRs.