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<article xlink="http://www.w3.org/1999/xlink" dtd-version="1.0" article-type="healthcare" lang="en"><front><journal-meta><journal-id journal-id-type="publisher">IJCRR</journal-id><journal-id journal-id-type="nlm-ta">I Journ Cur Res Re</journal-id><journal-title-group><journal-title>International Journal of Current Research and Review</journal-title><abbrev-journal-title abbrev-type="pubmed">I Journ Cur Res Re</abbrev-journal-title></journal-title-group><issn pub-type="ppub">2231-2196</issn><issn pub-type="opub">0975-5241</issn><publisher><publisher-name>Open Science Publishers LLP</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">4</article-id><article-id pub-id-type="doi"/><article-id pub-id-type="doi-url"/><article-categories><subj-group subj-group-type="heading"><subject>Healthcare</subject></subj-group></article-categories><title-group><article-title>ENHANCED DISSOLUTION AND BIOAVAILABILITY OF GRANISETRON HYDROCHLORIDE BY DIRECT COMPRESSION TECHNIQUE&#13;
</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>S.Patil</surname><given-names>Basawaraj</given-names></name></contrib><contrib contrib-type="author"><name><surname>Rao</surname><given-names>N.G.Raghavendra</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><day>30</day><month>06</month><year>2011</year></pub-date><volume>01</volume><issue>04</issue><fpage>1</fpage><lpage>9</lpage><permissions><copyright-statement>This article is copyright of Popeye Publishing, 2009</copyright-statement><copyright-year>2009</copyright-year><license license-type="open-access" href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.</license-p></license></permissions><abstract><p>In the present study, an attempt had been made to prepare fast dissolving tablets of the drug using, plantago ovata mucilage and sodium starch glycolate as super disintegrants (2.5 to 10 % w/w) following by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, carr__ampersandsignrsquo;s compressibility index and hausner__ampersandsignrsquo;s ratio. The tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, wetting time, in-vitro dispersion time and in-vitro dissolution study. Compare to sodium starch glycolate formulations, plantago ovata formulations shows faster release of drug, this is due to more swelling property of plantago ovata mucilage. In case of formulation GPO4, the 50% and 90% of drug release was found within 0.42 and 2.51min.The compatibility of drug with other ingredients was checked by FTIR studies, the results revealed that there was no interaction between dug and other excipients.&#13;
</p></abstract><kwd-group><kwd>Fast dissolving tablet</kwd><kwd> Granisetron  hydrochloride</kwd><kwd> Plantago ovata mucilage</kwd><kwd>  Sodium starch glycolate</kwd><kwd> superdisintegrants.</kwd></kwd-group></article-meta></front></article>
