Disability in leprosy affects the activities of daily life in all hemispheres. Dehabilitation, destitution, social isolation, all is associated with disability and social stigma. Hence prevention of disability and proper rehabilitation should be of prime concern. For preventing the disability and apt rehabilitation, it is essential to study the association between disability and social factors.Objective: 1) Tofind the strength of association between disability/deformity and social factors and 2. To study the genderdifference associated with social factors. Design: A cross sectional descriptive type of study. Subjects: 132 people affected by leprosy, living in leprosy colonies at Bijapur, Karnataka. India was involved in the study. Methodology: A house to house survey and interview was carried out using a preformed structured questionnaire.Chi square test and Z test was usedfor analysis and evaluation .Results: Significant association between family history of leprosy and Multi drug therapy (MDT) treatment taken was found regarding the disease and disability. Significant association between disability due to leprosy and its effect on jobs, social participation, physical dependency, financial dependency, use of assistive devices, relation with family members and neighbours, literacy, government aid provision. Significant difference was found between males and females affected by leprosy in following social aspects: relationship with family members, social participation, literacy, knowledge about leprosy, selfcare and use of assistive devices. Conclusion: Disability is associated with limitation of activities and social participation. Also disability and social stigma have its effect on social and family life, occupation and finance. Gender inequality makes the women suffer more as compared to males due social and cultural practices.