Background of study: Although acne is generally self-limited, it is found to have a great impact on patients__ampersandsignrsquo; lives. Objective: The purpose of the present study was to assess the impact of acne on Quality of Life in relation to gender, duration and severity of acne. Research Methodology: 100 male and 100 female patients with Acne vulgaris affecting the face between the age group 11-25 years were included in our study. After obtaining the history, the acne was graded into mild, moderate and severe based on the type and number of lesions. Dermatology Life Quality Index (DLQI) and Cardiff Acne Disability Index (CADI) were administered on the patients to measure the Quality of Life. Results: Based on the DLQI scores 81% had an effect on Quality of Life (QOL). The impact of acne was extremely large in 25% and very large in 56% of the study population. As per the CADI score 130 patients (65%) had a large impact on quality of life. The QOL in females was affected more than males based on CADI (p__ampersandsignlt;0.05) and there was a significant relation between the severity of acne and the impairment of QOL (P__ampersandsignlt;0.001). Conclusion: Female patients with Acne vulgaris have a poorer Quality of Life when compared to males and the severity of acne has a significant impact on Quality of Life.