Aim: This research aims to investigate the relationship between physical activity, diet and treatment of osteoporosis among postmenopausal women in 2024. Methodology: The method of this research is based on the purpose, applied and based on descriptive-survey data collection method of cross-sectional type. The data collection tool is a sample of library sources and studies and a researcher-made questionnaire, and the range of answering the questions is based on a 5-point Likert scale (very high, high, medium, low and very low). The statistical population of this research consists of postmenopausal women in the 11th district of Mashhad city, 80 of whom were selected by purposive sampling. Results: The findings of this research show that movement along with natural foods can be effective in dealing with the reduction of bone density and loss of bone tissue, especially during estrogen deficiency, lack of anti-inflammatory control and lack of antioxidants in postmenopausal women. The results of this research have shown a positive relationship with the increase of combined interventions, but some data do not show any additional and additional effects and effectiveness, which may be influenced by the choice of exercise and training regime and the consumption dose of natural foods. Therefore, the effect and mechanism of combination therapy still require further research with extensive experimental data. Conclusion: Exercise and physical activity and natural foods have a lot of potential and advantages at a very low cost, while being non-toxic and have other advantages, which are widely considered and valued by the medical community.