Wound healing is a multifaceted and intricate process which encompasses the rejuvenation of impaired cells and the reconstitution of tissue structure. The duration of this tailoring journey can range from immediate to long span of years. For futuristic healthcare system, the advancement of wound healing and tissue engineering holds paramount significance. Recently, there has been a surge in the adoption of biomaterial-assisted therapeutic approaches, exhibiting promising outcomes in expediting the wound healing and skin restoration processes. Being one of the easily available biomaterials, the natural polymers have gained importance due to their biocompatibility, biodegradability and tissue regeneration. These polymers are presently employed as natural scaffold for wound dressing formulations. The present review aims to elucidate the fundamental principles as well as the recent advancements in wound healing and tissue repair strategies, and additionally, it delves into the origins and applications of various natural polymers.