Chewing gums are mobile drug delivery systems, with a potential for administering drugs either for local or systemic absorption via buccal route. It can be administered discreetly without water. Medicated Chewing Gums contains gum base along with antiemetic agent which is intended to chew not to be swallowed. Domperidone is a dopamine receptor antagonist used as a peristaltic stimulant and anti-emetic agent for dyspepsia, indigestion, epigastric pain, nausea, and vomiting. It is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. It is a small molecule, approved, investigational, vet approved with molecular weight of 425.911 and molecular formula of C22H24ClN5O2. These formulations contain domperidone maleate, gum base, sorbitol, sucrose, lactose, calcium carbonate, and talc. The medicated chewing gums were prepared by the direct compression method. The prepared formulations were evaluated for various pre-compression and post-compression parameters. From the results, it is concluded that the chewing gum containing domperidone maleate will be the potential dosage form for the treatment of chemotherapy induced nausea and vomiting.