Millions of people throughout the globe rely on traditional medicines as part of their alternative health care systems. In contrast to contemporary pharmaceuticals, which are single molecules that have undergone extensive testing, structural optimization, and toxicological clearance, traditional herbal remedies are multi-constituent treatments whose safety and effectiveness is dependent on the experiences of practitioners. More than 80% of today__ampersandsignrsquo;s pharmaceuticals come from natural sources (plants, bacteria, cells, etc.), either as the original molecules or as synthetic versions of the original chemicals. Diarrhea and similar gastrointestinal diseases are treated using a wide variety of medicinal herbs used in traditional medicine. The effectiveness of several of these plants in treating diarrhea in animal models has been shown by science. Unfortunately, only a small fraction of these have been subjected to rigorous clinical trial testing. Several traditional anti-diarrheal medicinal herbs are discussed, and their effectiveness in in-vivo models is highlighted. While a small number of active phytomolecules have been isolated from these plants, their potential therapeutic use and safety have not been thoroughly investigated. The prospective herbal extracts that might be researched for the discovery of new active molecules against diarrhea and other gastrointestinal illnesses are also described in this study. The development of innovative, effective, and safe phyto-medicines for fighting diarrhea and related illnesses will need rigorous clinical studies of lead plants/phyto-molecules.