Systemic and topical antimicrobials are effective in the treatment of inflammatory acne vulgaris; however, widespread use of these agents is becoming increasingly associated with the emergence of resistant pathogens raising concerns about microorganism resistance and highlighting the need for alternative non-antimicrobial agents for the treatment of acne. Several multinational companies like Lakme Cosmetics Ltd., Lotus Ltd., Ayur Healthcare Ltd., Patanjali Ayurveda, etc. have started developing anti-acne products which contain multiple extracts of common Indian plants. The study aims to develop herbal gel formulations containing Bougainvillea glabra extract (aqueous, methanol, ethyl acetate, and petroleum ether) for the treatment of acne. The formulations were comprehensively evaluated for Physical evaluation, Washability, Skin irritation test, Spreadability, pH, Viscosity, Extrudability, Swelling index, and Accelerated stability studies as per the standard methods. Amongst all the formulations studied, batch F2 was found optimum for all the parameters. The extraction yield was found to be 11.21%. Bougainvillea glabra aqueous extract showed low anti-bacterial activity whereas both Bougainvillea glabra methanol extract and Bougainvillea glabra ethyl acetate extract expressed moderate anti-bacterial activity with average MIC value against E. coli and B. subtilis. In contrast to them, the petroleum ether extract of Bougainvillea glabra presented highest anti-bacterial activity, however, the activity was less pronounced than the standard drug Clindamycin. The formulations (F1-F4) represented alike results with that of the extracts and expressed lesser activity as compared to the marketed herbal product.