Introduction: Ayurvedic medications are extensively used across the world for illness prevention and treatment. The active ingredients of Coroprotect dry syrup are Jethimadh ext, Ajma ext., Tulsi ext., Pipper ext., Sunth ext., Kalamari ext., Vasa ext., Taj ext., Lavang ext., Nagarvel ext., Haridra ext., Kakamachi ext., Pushkarmool ext., and Phudina ful, etc. Because there is no scientific proof that this formulation is safe, a comprehensive toxicity study in wistar rats was conducted. Objective: In Rodents, acute and subacute toxicity of coroprotect dry syrup was studied after a single and repeated 28-day oral dosage Administration. Method: Six Wistar female rats were given a single dose of coroprotect dry syrup at 2000 mg/kg by oral gavage, while doses of 100, 200 and 500 mg/kg/day were given over the course of 28 days in a repeated-dose subacute toxicity study. Results: In an acute toxicity investigation involving coroprotect dry syrup administration, no therapies fatalities or toxic symptoms were found. In the repeated dosage study, there were no substantial differences in body weight fluctuations, food/water ingestion, hematology, or clinical biochemistry content among the control as well as coroprotect dry syrup groups. There were no gross pathological abnormalities or variations in relative organ weights between the control and coroprotect dry syrup groups. Histopathological investigation revealed no abnormalities after therapy with coroprotect dry syrup. Conclusion: In a repeated dosage toxicity study in rodents, the coroprotect dry syrup was determined to be safe at all dose levels.