With 8.8 million people dying each year, cancer is the world__ampersandsignrsquo;s second-largest cause of mortality. Kidney cancer, prostate cancer, colorectal cancer, stomach cancer, and liver cancer are more common in males, whereas breast cancer, colorectal cancer, lung cancer, cervical cancer, and stomach cancer are more common in women. Several medicines, such as taxanes like paclitaxel and vinca alkaloids like vincristine and vinblastine, are derived from plants and are approved by the US Food and Drug Administration (USFDA) for use in cancer therapy. Nonetheless, a range of bioactive sources must be identified as soon as possible in order to develop a novel anti-cancer therapy for this chronic illness. More than thirty plant-derived natural compounds have been identified and are now being tested in clinical studies. According to a literature study of numerous papers and texts, novel therapeutic compounds generated from bioactive sources have been proven to be therapeutically efficacious against various types of cancer cells. The present study focuses on new therapeutic compounds derived from plants that have been proven in clinical trials to cure a range of malignancies. This paper also provided and analyzed the most significant findings of these effective new therapeutic medicines.