A virosome is a revolutionary hybrid drug delivery system that combines the advantages of viral and non-viral vectors. According to the study, virosomes may carry a range of physiologically active molecules such as nucleic acids, peptides, proteins, and small chemical compounds. Surface modifications in virosomes might be leveraged to allow for tailored drug administration using virosome-based devices. On the market today, there are a number of virosome-based preventative and therapeutic drugs with outstanding safety profiles. Cancer treatment is a key battlefield for virosome-based medication delivery technologies. This research covers the fundamental concept, manufacturing techniques, operating mechanisms, preclinical studies, and clinical applications of virosomes.