Oral administration is the most basic, cost-effective, and significant method of pharmaceutical administration. As a consequence, scientists have struggled to improve dose formulations, especially for extended-release applications. Low bioavailability, protection from the harsh stomach environment, and protection from degrading gastric enzymes are all challenges that vesicular drug delivery techniques were devised to solve. Emulsomes are a novel lipoidal vesicular system with an internal solid fat core coated by a phospholipid bilayer that avoids many of the flaws of prior systems. This method is designed to be used as a carrier for poorly soluble medications. Emulsomes enclose the drug, allowing it to remain in the systemic circulation for longer. Also becoming more frequently available are emulsomal-based formulations of genetic medications with evident systemic use, such as antisense oligonucleotides and plasmids for gene therapy. This study analyses the idea of emulsomal drug delivery, describes the effectiveness of emulsomes for the delivery of small molecules, and focuses on formulation design, benefits, biopharmaceutical features, stability issues, and other elements of drug delivery, as well as future considerations.