Vesicular systems have shown to be highly successful carrier systems in a range of scientific domains. Sphingosomes are bi-layered vesicles with an aqueous volume entirely enclosed by a membrane lipid bilayer mostly composed of natural or synthetic sphingolipid. Sphingosomes solve some of the vesicle system__ampersandsignrsquo;s major shortcomings (liposomes, niosomes), such as instability, in vivo circulation time, and tumor loading efficacy in cancer therapy. The material was gathered using the term Sphingosomes in the Google Scholar and Scopus databases. Sphingosomes are used to deliver chemotherapeutic drugs, biological macromolecules, and diagnostics in clinical settings. As a consequence of their size and composition flexibility, many types of sphingosomes have been developed. According to the conclusions of this research, sphingosomes are a possible vesicular drug delivery system that might carry medicinal compounds for a range of applications.