Cubosomes are nanoparticles that are square or rounded and have internal cubic lattices. Cubosomes are a one-of-a-kind creation that combines food science, differential geometry, biological membranes, and digestion into a single entity. Because of its discovery and nomination, self-assembled cubosomes have developed in appeal as excellent drug delivery methods. Cubosomes are thermodynamically stable and contain a honeycomb-like structure of bicontinuous water and lipid domains. It is produced into bilayers inside the surfactant and wrapped into a three-dimensional, intermittent, and minimum surface, resulting in a densely packed structure. The material is a bicontinuous cubic liquid crystalline form that is optically clear and very viscous, with a unique composition in the nanometer range. Overall, cubosomes are critical in nano-drug preparations for melanoma treatment because to their intrinsic benefits, which include higher surface area and cuboidal structures, which allow for larger drug payloads. They__ampersandsignrsquo;re easy to make, and their biodegradability allows them to encapsulate hydrophobic, hydrophilic, and amphiphilic chemicals while releasing bioactive substances in a regulated manner. Dispersion of biocompatible and bioadhesive cubosomes Cubosomes are tiny structures that may be administered in a variety of methods, including oral, percutaneous, and parenteral, due to their features. Cubosomes have a wide range of uses and are represented by a number of characteristics. As a result, cubosomes are gaining in popularity in the pharmaceutical testing industry.