Objectives: This study was aimed at investigating the awareness of spontaneous ADR reporting among medical students in a teaching hospital in Kerala, and to analyze the impact of an interventional lecture about pharmacovigilance on the same. Methods: This was a questionnaire based study conducted among 118 medical students at a tertiary care teaching hospital. Each participant was explained the purpose of study and asked to fill in a questionnaire about their knowledge and awareness of pharmacovigilance. All of them attended the lecture on pharmacovigilance and they were allowed to fill the same questionnaire again. Based on the number of correct answers, a scoring had been done. Results: 82% of the participants knew about ADR reporting system in India. Majority of the respondents (88%) knew that, as medical students, they could report ADRs but were unaware about the methodology to report (63.5%). All participants responded that clinicians and medical students should be trained for ADR reporting. Educational intervention had improved their knowledge and awareness significantly which was supported by an increase in mean score from 9.74 to 11.92 (p __ampersandsignlt; 0.001) after the lecture. Majority of them (94.1%) agreed that all sort of ADRs should be reported. Conclusion: Attitude towards ADR reporting was positive but knowledge about ADR reporting system was inadequate among medical students in a teaching hospital in Kerala. The study strongly suggested that there was a need to create awareness about pharmacovigilance among the medical students and awareness programmes should be made an integral part of medical education.