Background and Aim: Strokes (cerebrovascular accidents) are considered to be one of the most common causes of mortality and long term severe disability. Changes in the lipid profile have been suggested as a risk factor for developing ischemic stroke. It is well documented that hyperlipidaemia is a powerful risk factor for ischemic heart disease. The present study was conducted to establish the role of serum fibrinogen and lipid profile levels in cerebrovascular accident Methods: The study comprised 50 cerebrovascular accident patients consisting of 35 men and 15 women with mean age 55.54 years and 30 age and gender matched apparently healthy subjects. Plasma fibrinogen levels, high-density lipoprotein cholesterol (HDLc), low-density lipoprotein cholesterol (LDL-c), total cholesterol (TC), were measured, using enzymatic colorimetric methods in both patients and controls. Results: The mean fibrinogen levels is higher in cases 492.1 mg/dl than in controls is 318.33mg/dl The mean total cholesterol is high in cases is 215.9 + 26.68 mg/dl than in controls is 180.7 + 25.28 mg/dl . The mean LDL cholesterol in cases is 148.1 + 26.96 mg/dl. The Mean value of HDL cholesterol in cases is 39.4 + 2.75 mg/dl than in controls 60.24 + 11.47 mg/dl. The Mean plasma fibrinogen levels are more in the second sample 595.9 mg/dl compared to first sample 395.2 mg/dl and it is statistically significant with t value 11.43 and P value __ampersandsignlt; 0.005. Conclusion: The study concludes rise of fibrinogen in smokers .Hyperlipidemias are positively associated with rise in fibrinogen in ischemic stroke patients. Especially LDL cholesterol __ampersandsignamp; Total Cholesterol were raised with fibrinogen. Thus hypertension and hyperfibrinogenemia in combination act as risk factors and contribute to the pathogenesis of ischemic stroke. Fibrinogen is significantly raised 15 days after stroke which indicates that it is an acute phase reactant and has a role in the progression of atherosclerotic process in ischemic stroke patients.