Background: Pain management has always been an important part of dental care. Quality use of analgesics is thus paramount in the safe and effective management of dental pain. Objectives: to determine the quality use analgesics in dental out patient in Jimma University Specialized Hospital. Method: In total 302 patient cards were reviewed from 22/01/2013-27/01/2013. Data were analyzed by using SPSS version 19.0.The age and sex distribution, the case and analgesic prescribed for each case were determined by descriptive statistics method __ampersandsignldquo;frequency__ampersandsignrdquo; Results: There were more female patients (55%) than male patients (45%) in this study. The dental disorders most frequently reported in this study were diseases of pulp and periapical tissue (49%). Most of the non-opioid analgesics were administered orally. The most commonly prescribed non-opioid analgesic was Diclofenac (43%) followed by Paracetamol (36%). In total 2.2% analgesics were prescribed concomitantly with gastro protective agent (Omeprazole). All gastro protective agents (7) were prescribed concomitantly with non-opioid analgesics only. No gastro protective agents were used with opioid analgesic. Conclusion: The prescription analysis demonstrated that pain was neglected and the analgesics available are irrationally used. Moreover, the absence of opiods analgesics in the clinical settings is confirmed by this study