Background: Surgical methods of acute myocardial infarction (MI) treatment possess a high clinical effectiveness, but at the same time, there are fixed limitations, related to the patient?s state, which is limited by medical resources and organizational problems. The development of new medical technologies allows for a better and effective non-surgical treatment of acute MI and increase longterm prognosis in this category of patients. Aim: We assessed the influence of hyperbaric oxygenation therapy on mortality rate and recurrent myocardial infarction (rMI) within 5-years monitoring. Materials and methods: The study involved 697 patients who suffered from acute MI, having undergone the standard therapy. The patients were divided at random into 2 groups: Group 1 (reference group, n=363); Group 2 (test group, n=334). Group 2 patients were given the traditional treatment, accompanied with HBOT (isopression for 40 minutes at a working pressure of 0.03 MPa). HBOT was applied on the 1st __ampersandsignndash; 5 th day following MI, the treatment course included 6 cycles, once per day. The clinical assessment was focused on clinical outcome: repeated MI eventuality and cardiovascular related mortality. Monitoring duration was 5 years. Results: HBOT application that accompanied the acute MI traditional pharmacotherapy proved to reduce rMI within 5 years following inpatient discharge (rate of rMI was 14% in the reference group and 5.4% in the test group, __ampersandsignchi; 2 =13.25, ?__ampersandsignlt;0.05). The joint application of HBOT and traditional technology in treating acute MI makes it possible to raise the 5-year survival rate from 84.4% up to 95.9%.