Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2024May25Pharmaceutical SciencesDesign, Development and Characterization of Novel Ranitidine-Loaded Mucoadhesive Delivery System     English0110Garima PandeyEnglish Surendra DangiEnglish Bhaskar Kumar GuptaEnglishhttps://doi.org/10.31782/IJMPS.2024.14501Aim: The study aims to develop and evaluate floating tablet formulations of ranitidine to overcome its short half-life (1.2–1.9 hours) and maintain stable plasma drug levels. This approach seeks to enhance drug bioavailability through gastroretentive systems using rate-modifying polymers. Methodology: Nine ranitidine floating tablet formulations (F1-F9) were prepared using a multiple punch tablet compression machine with 9 mm round flat-faced punches, each containing 80 mg of ranitidine. Hydroxypropyl methylcellulose (HPMC K15M, HPMC K100M) and xanthan gum were used as rate-modifying polymers. Drug-polymer compatibility was assessed using Fourier-Transformed Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC). The formulations were evaluated for pre-compression parameters (bulk density, tapped density, Carr’s index, Hausner’s ratio, angle of repose) and post-compression characteristics (hardness, friability, weight variation, drug content, swelling index, buoyancy, and in vitro drug release). Accelerated stability studies were performed for 90 days, and drug release kinetics were analyzed. Results: The floating ranitidine tablets demonstrated optimal buoyancy and extended drug release profiles. Compatibility studies confirmed no significant drug-polymer interactions. All formulations met pharmacopeial standards for physical parameters. In vitro drug release studies showed sustained drug release over several hours, and stability tests confirmed the formulations’ robustness. Conclusion: The developed floating tablets successfully prolonged the release of ranitidine, enhancing its half-life and maintaining steady plasma drug levels. This formulation strategy could serve as a foundation for future advancements in anti-retroviral pharmacotherapeutics, improving patient compliance and therapeutic outcomes. EnglishRanitidine, Mucoadhesive, Tablet, Gastroretentive, Xanthan, Floatinghttp://ijcrr.com/abstract.php?article_id=251http://ijcrr.com/article_html.php?did=2511. Badoni A, Ojha A, Gnanarajan G, Kothiyal P. Review on gastro retentive drug delivery system. Pharm. Innovat. 2012;1(8):32- 46. 2. Dehghan M, Kha F. Gastroretentive drug delivery systems: A patent perspective. Int. J. Health Res. 2009;2(1):23-44. 3. Gurnany E, Singhai P, Soni A, Jain R, Jain SK, Jain A. Gastro Retentive Drug Delivery System-A Review. J. Pharm. Res. 2011;4(6):1899-1908. 4. Joshi P, Patel P, Modi H, Patel MR, Patel KR, Patel NM. A review on gastroretentive drug delivery system. J. Pharm. Sci. Biosci. Res. 2012;2(3):123-128. 5. Khan R. Gastroretentive drug delivery system-a review. Int. J. Pharm. Bio. Sci. 2013;4(2):630-646. 6. Makwana A, Sameja K, Parekh H, Pandya Y. Advancements in controlled release gastroretentive drug delivery system: A review. J. Drug Deliv. Ther. 2012;2(3):12-21. 7. Mehta M, Pandey P, Mahajan S, Satija S. Gastro retentive drug delivery systems: An overview. Res. J. Pharm. Technol. 2018;11(5):2157-2160. 8. Nayak AK, Malakar J, Sen KK. Gastroretentive drug delivery technologies: Current approaches and future potential. J. Pharm. Edu. Res. 2010;1(2):1-12. 9. Patel N, Nagesh C, Chandrashekhar S, Jinal P, Devdatt J. Floating drug delivery system: an innovative acceptable approach in gastro retentive drug delivery. Asian J. Pharm. Res. 2012;2(1):7-18. 10. Rathod HJ, Mehta DP, Yadav JS. A review on Gastroretentive Drug Delivery Systems. PharmaTutor. 2016;4(7):29-40. 11. Sharma D, Sharma A. Gastroretentive drug delivery system-a mini review. Asian Pac. J. Health Sci. 2014;1(2):80-89. 12. Shinde S, Tadwee I, Shahi S. Gastro retentive drug delivery system: A review. Int. J. Pharm. Res. All. Sci. 2012;1(1):1-13. 13. Siraj S, Khurshid M, Nazim S. Various perspectives of gastro retentive drug delivery system; A Review. Am. J. Adv. Drug Deliv. 2013;1(4):443-451.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2024May25Pharmaceutical SciencesInvestigating the relationship between physical activity, diet and osteoporosis treatment (Study of postmenopausal women) English1118Samira Abedi SarasiaEnglishSamira Abedi Sarasia, Expert in Physical Education and Sports Sciences, Payam Noor Mashhad University, Mashhad, Iran.https://doi.org/10.31782/IJMPS.2024.14502Aim: This research aims to investigate the relationship between physical activity, diet and treatment of osteoporosis among postmenopausal women in 2024. Methodology: The method of this research is based on the purpose, applied and based on descriptive-survey data collection method of cross-sectional type. The data collection tool is a sample of library sources and studies and a researcher-made questionnaire, and the range of answering the questions is based on a 5-point Likert scale (very high, high, medium, low and very low). The statistical population of this research consists of postmenopausal women in the 11th district of Mashhad city, 80 of whom were selected by purposive sampling. Results: The findings of this research show that movement along with natural foods can be effective in dealing with the reduction of bone density and loss of bone tissue, especially during estrogen deficiency, lack of anti-inflammatory control and lack of antioxidants in postmenopausal women. The results of this research have shown a positive relationship with the increase of combined interventions, but some data do not show any additional and additional effects and effectiveness, which may be influenced by the choice of exercise and training regime and the consumption dose of natural foods. Therefore, the effect and mechanism of combination therapy still require further research with extensive experimental data. 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