Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2023January31Pharmaceutical SciencesNanotechnology: Reviewing the New Concept of Drug Delivery     English0108Mojabir Hussen AnsariEnglish Sonam S. YadavEnglishMojabir Hussen Ansari, Assistant Professor at Ram Sharan Roy College of Pharmacy, Panapur, Makkanpur, Jandaha, Vaishali, Bihar 844505, India https://doi.org/10.31782/IJMPS.2023.13101Nanotechnology is mostly applied in pharmaceutical research for so many reasons, but the real goals are to improve or enhance drug solubility/bioavailability and/or delivery to specific sites of action. Nanotechnology is also used to develop new and effective therapeutic devices. Nanotechnology involves the systematic study of smaller molecular structures with a size range between 0.1 to 100 nm. It is useful in various areas like the subspecialties of medicine such as cardiology, ophthalmology, endocrinology, cancer, and immunology, as well as biophysics, molecular biology, and bioengineering. Pharmaceutical Nanotechnology depends on the methods and principles of Nanoscience and nano medicine to pharmacies to develop new drug delivery systems which can overcome the drawbacks or limitations of conventional drug delivery systems. English Nanotechnology, Nano research, Therapeutics, Nano particleshttp://ijcrr.com/abstract.php?article_id=218http://ijcrr.com/article_html.php?did=2181. Patra, J.K., 2018. Gitishree Das, Leonardo Fernandes Fraceto, Estefania Vangelie Ramos Campos, Maria del Pilar Rodriguez Torres, et al. Nano-based drug delivery systems: recent developments and prospects. Journal of Nanobiotechnology, 16(1). 2. Muntha, P., Research and Reviews: Journal of Pharmacy and Pharmaceutical Sciences. 3. Chapman, P., 2005. Nanotechnology in the pharmaceutical industry. Expert opinion on therapeutic patents, 15(3), pp.249- 251. 4. Mazayen, Z.M., Ghoneim, A.M., Elbatanony, R.S., Basalious, E.B. and Bendas, E.R., 2022. Pharmaceutical nanotechnology: from the bench to the market. Future Journal of Pharmaceutical Sciences, 8(1), pp.1-11. 5. Nikhade, N., Telrandhe, R. and Ansari, M., 2019. A Review of Natural Antioxidants In Medicinal Plants. International Journal of Pharmaceutics and Drug Analysis, pp.11-15. 6. Mazayen, Z.M., Ghoneim, A.M., Elbatanony, R.S., Basalious, E.B. and Bendas, E.R., 2022. Pharmaceutical nanotechnology: from the bench to the market. Future Journal of Pharmaceutical Sciences, 8(1), pp.1-11. 7. Karuppusamy, C. and Venkatesan, P., 2017. Role of nanoparticles in drug delivery system: a comprehensive review. Journal of Pharmaceutical sciences and Research, 9(3), p.318. 8. Basu, B. and Mehta, G., 2014. Carbon nanotubes: a promising tool in drug delivery. 9. Singh, B.G.P., Baburao, C., Pispati, V., Pathipati, H., Muthy, N., Prassana, S.R.V. and Rathode, B.G., 2012. Carbon nanotubes. A novel drug delivery system. International Journal of Research in Pharmacy and Chemistry, 2(2), pp.523-532. 10. Paliwal, S., Pandey, K., Pawar, S., Joshi, H. and Bisht, N., 2020. A Review on Carbon Nanotubes: As a Nanocarrier Drug Delivery System. Indian Journal of Pharmaceutical Sciences, 82(5), pp.766-772. 11. Basu, B. and Mehta, G., 2014. Carbon nanotubes: a promising tool in drug delivery. 12. Digge, M.S., Moon, R.S. and Gattani, S.G., 2012. Applications of carbon nanotubes in drug delivery: a review. International Journal of Pharm Tech Research, 4(2), pp.839-847. 13. Anees, M., Masood, M.I., Ilyas, M. and Ammad, M., 2016. Nanoparticles as a novel drug delivery system a review. Pakistan Journal of Pharmaceutical Research, 2(2), p.160. 14. Kah, J.C., Phonthammachai, N., Wan, R.C., Song, J., White, T., Mhaisalkar, S., Ahmadb, I., Shepparda, C. and Olivoc, M., 2008. Synthesis of gold nanoshells based on the deposition precipitation process. Gold Bulletin, 41(1), pp.23-36. 15. Brito-Silva, A.M., Sobral-Filho, R.G., Barbosa-Silva, R., de Arau?jo, C.B., Galembeck, A. and Brolo, A.G., 2013. Improved synthesis of gold and silver nanoshells. Langmuir, 29(13), pp.4366-4372. 16. Hirsch, L.R., Gobin, A.M., Lowery, A.R., Tam, F., Drezek, R.A., Halas, N.J. and West, J.L., 2006. Metal nanoshells. Annals of biomedical engineering, 34(1), pp.15-22. 17. Ji, X., Shao, R., Elliott, A.M., Stafford, R.J., Esparza-Coss, E., Bankson, J.A., Liang, G., Luo, Z.P., Park, K., Markert, J.T. and Li, C., 2007. Bifunctional gold nanoshells with a superparamagnetic iron oxide− silica core suitable for both MR imaging and photothermal therapy. The Journal of Physical Chemistry C, 111(17), pp.6245-6251. 18. Ahmadi, A. and Arami, S., 2014. Potential applications of nanoshells in biomedical sciences. Journal of drug targeting, 22(3), pp.175-190. 19. Wu, J., Zhang, K., Cen, C., Wu, X., Mao, R. and Zheng, Y., 2021. Role of bulk nanobubbles in removing organic pollutants in wastewater treatment. AMB Express, 11(1), pp.1-13. 20. Khan, P., Zhu, W., Huang, F., Gao, W. and Khan, N.A., 2020. Micro–nanobubble technology and water-related application. Water Supply, 20(6), pp.2021-2035. 21. Kyzas, G.Z., Mitropoulos, A.C. and Matis, K.A., 2021. From microbubbles to nanobubbles: effect on flotation. Processes, 9(8), p.1287. 22. Tekile, A., Kim, I. and Lee, J.Y., 2017. Applications of ozone micro-and nanobubble technologies in water and wastewater treatment. Journal of Korean Society of water and wastewater, 31(6), pp.481-490. 23. Eklund, F., 2019. Nanobubbles in Water–How to Identify Them and Why They Are Stable (Doctoral dissertation, Chalmers Tekniska Hogskola (Sweden)). 24. Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S.W., Zarghami, N., Hanifehpour, Y., Samiei, M., Kouhi, M. and Nejati-Koshki, K., 2013. Liposome: classification, preparation, and applications. Nanoscale research letters, 8(1), pp.1-9. 25. Laouini, A., Jaafar-Maalej, C., Limayem-Blouza, I., Sfar, S., Charcosset, C. and Fessi, H., 2012. Preparation, characterization and applications of liposomes: state of the art. Journal of colloid Science and Biotechnology, 1(2), pp.147-168. 26. Choudhury, A., Sonowal, K., Laskar, R.E., Deka, D. and Dey, B.K., 2020. Liposome: a carrier for effective drug delivery. Journal of Applied Pharmaceutical Research, 8(1), pp.22-28. 27. Sherpa, L.S., Kumar, I., Chaudhary, A. and Lepcha, B., 2020. Liposomal Drug Delivery System: Method of Preparations and Applications. Journal of Pharmaceutical Sciences and Research, 12(9), pp.1192-1197. 28. Rajera, R., Nagpal, K., Singh, S.K. and Mishra, D.N., 2011. Niosomes: a controlled and novel drug delivery system. Biological and Pharmaceutical Bulletin, 34(7), pp.945-953. 29. Mujoriya, R., Bodla, R.B., Dhamande, K., Singh, D. and Patle, L., 2011. Niosomal drug delivery system: the magic bullet. Journal of Applied Pharmaceutical Science, 1(9), pp.20-23. 30. Arunachalam, A., Jeganath, S., Yamini, K. and Tharangini, K., 2012. Niosomes: a novel drug delivery system. International Journal of Novel Trends in Pharmaceutical Sciences, 2(1), pp.25-31. 31. Durak, S., Esmaeili Rad, M., Alp Yetisgin, A., Eda Sutova, H., Kutlu, O., Cetinel, S. and Zarrabi, A., 2020. Niosomal drug delivery systems for ocular disease—recent advances and future prospects. Nanomaterials, 10(6), p.1191. 32. Abbasi, E., Aval, S.F., Akbarzadeh, A., Milani, M., Nasrabadi, H.T., Joo, S.W., Hanifehpour, Y., Nejati-Koshki, K. and Pashaei-Asl, R., 2014. Dendrimers: synthesis, applications, and properties. Nanoscale research letters, 9(1), pp.1-10. 33. Chis, A.A., Dobrea, C., Morgovan, C., Arseniu, A.M., Rus, L.L., Butuca, A., Juncan, A.M., Totan, M., Vonica-Tincu, A.L., Cormos, G. and Muntean, A.C., 2020. Applications and limitations of dendrimers in biomedicine. Molecules, 25(17), p.3982. 34. Knecht, M.R., Weir, M.G., Myers, V.S., Pyrz, W.D., Ye, H., Petkov, V., Buttrey, D.J., Frenkel, A.I. and Crooks, R.M., 2008. Synthesis and characterization of Pt dendrimer-encapsulated nanoparticles: effect of the template on nanoparticle formation. Chemistry of materials, 20(16), pp.5218-5228. 35. Castro, R.I., Forero-Doria, O. and Guzman, L., 2018. Perspectives of dendrimer-based nanoparticles in cancer therapy. Anais da Academia Brasileira de Ciências, 90, pp.2331-2346. 36. Niu, Y. and Crooks, R.M., 2003. Dendrimer-encapsulated metal nanoparticles and their applications to catalysis. Comptes Rendus Chimie, 6(8-10), pp.1049-1059. 37. Croy, S.R. and Kwon, G.S., 2006. Polymeric micelles for drug delivery. Current pharmaceutical design, 12(36), pp.4669-4684. 38. Mourya, V.K., Inamdar, N., Nawale, R.B. and Kulthe, S.S., 2011. Polymeric micelles: general considerations and their applications. Indian J Pharm Educ Res, 45(2), pp.128-38. 39. Parra, A., Jarak, I., Santos, A., Veiga, F. and Figueiras, A., 2021. Polymeric Micelles: A Promising Pathway for Dermal Drug Delivery. Materials, 14(23), p.7278. 40. Chinju, M. and Kripa, S., 2020. A Comprehensive Review on Polymeric Micelles. Int. J. Pharm. Sci. Rev. Res, 61(2), pp.36- 39. 41. Grallert, S.R.M., Rangel-Yagui, C.D.O., Pasqualoto, K.F.M. and Tavares, L.C., 2012. Polymeric micelles and molecular modeling applied to the development of radiopharmaceuticals. Brazilian Journal of Pharmaceutical Sciences, 48, pp.1-16. 42. Wang, X., Hall, J.E., Warren, S., Krom, J., Magistrelli, J.M., Rackaitis, M. and Bohm, G.G., 2007. Synthesis, characterization, and application of novel polymeric nanoparticles. Macromolecules, 40(3), pp.499-508. 43. Zieli?ska, A., Carreiró, F., Oliveira, A.M., Neves, A., Pires, B., Venkatesh, D.N., Durazzo, A., Lucarini, M., Eder, P., Silva, A.M. and Santini, A., 2020. Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology. Molecules, 25(16), p.3731. 44. Wang, H. and Rempel, G.L., 2015. Introduction of polymer nanoparticles for drug delivery applications. J Nanotechnol Nanomed Nanobiotechnol, 2(008). 45. Ozakar, E., Cetin, M., Ates, O. and Hacimuftuoglu, A., 2019. Nifedipine-loaded polymeric nanoparticles: Preparation and in vitro characterization. Pakistan Journal of Pharmaceutical Sciences, 32(2). 46. Mayer, C., 2005. Nanocapsules as drug delivery systems. The International journal of artificial organs, 28(11), pp.1163-1171. 47. Deng, S., Gigliobianco, M.R., Censi, R. and Di Martino, P., 2020. Polymeric nanocapsules as nanotechnological alternative for drug delivery system: current status, challenges and opportunities. Nanomaterials, 10(5), p.847. 48. Poletto, F.S., Beck, R.C., Guterres, S.S. and Pohlmann, A.R., 2011. Polymeric nanocapsules: concepts and applications. Nanocosmetics and nanomedicines, pp.49-68. 49. Reis, C.P., Neufeld, R.J., Ribeiro, A.J. and Veiga, F., 2006. Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine, 2(1), pp.8-21. 50. Mahajan, H. and Savale, S.K., 2016. Nanoemulsion: A versatile mode of drug delivery system. Indian journal of novel drug delivery, 8(3), pp.123-132. 51. Sharma, N., Bansal, M., Visht, S., Sharma, P.K. and Kulkarni, G.T., 2010. Nanoemulsion: A new concept of delivery system. Chronicles of Young Scientists, 1(2), pp.2-6. 52. Gupta, A., Eral, H.B., Hatton, T.A. and Doyle, P.S., 2016. Nanoemulsions: formation, properties and applications. Soft matter, 12(11), pp.2826-2841. 53. Azmi, N.A.N., Elgharbawy, A.A., Motlagh, S.R., Samsudin, N. and Salleh, H.M., 2019. Nanoemulsions: Factory for food, pharmaceutical and cosmetics. Processes, 7(9), p.617. 54. Shah, P., Bhalodia, D. and Shelat, P., 2010. Nanoemulsion: A pharmaceutical review. Systematic reviews in pharmacy, 1(1). 55. Gurpreet, K. and Singh, S.K., 2018. Review of nanoemulsion formulation and characterization techniques. Indian Journal of Pharmaceutical Sciences, 80(5), pp.781-789.

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2023January31Pharmaceutical SciencesRecent Formulation Development Advances and Drug Delivery Insights for Medicated Chewing Gums     English0918Jyoti Kiran SahuEnglish Suruchi PrasadEnglishMs. Suruchi Prasad, M. Pharm, Assistant Professor, Department of Pharmaceutics, School of Pharmacy, Chouksey Engineering College, Bilaspur 495004, Chhattisgarh, Indiahttps://doi.org/10.31782/IJMPS.2023.13102Oral medication delivery system research has resulted in the development of new formulations and technology. Such studies demonstrate the importance of the oral route among patients. We’ve gone through all of the benefits and drawbacks of medicated chewing gum as a contemporary medication delivery system, including the history, benefits and drawbacks, production processes, composition variations, assessment tests, and samples of different medicated chewing gum kinds. The acceptance of medicated chewing gum has grown over time. Chewing gum’s advantages and therapeutic benefits encourage its development, as shown by the fact that new formulations including new pharmaceuticals have been generated in the past and will be found in the market by the formation of new medicated chewing gums. Medicated chewing gums have a broad range of potential uses that will be identified in the future. Chewing gums now have the same qualification criteria as pills. Patients’ compliance is improved by using medicated chewing gums as a delivery strategy in patient-centered research. EnglishMedicated chewing gum, Formulation, Drug delivery, Manufacturing, Evaluation, Productshttp://ijcrr.com/abstract.php?article_id=224http://ijcrr.com/article_html.php?did=2241. Gutiérrez-López GF, Welti-Chanes J, Parada-Arias E. Food engineering: integrated approaches: Springer; 2008. 2. Portal TS. Chewing gum market—statistics & facts. 2015 [cited 2018 1 Feb]; Available from: https://www.statista.com/topics/ 1841/chewing-gum/. 3. Konar N, Palabiyik I, Toker OS, Sagdic O. Chewing gum: production, quality parameters and opportunities for delivering bioactive compounds. Trends Food Sci Technol. 2016;55:29–38. 4. Aslani A, Rostami F. Medicated chewing gum, a novel drug delivery system. J Res Med Sci. 2015;20(4):403–11. 5. Rassing MR. Chewing gum as a drug delivery system. Adv Drug Deliv Rev. 1994;13(1–2):89–121. 6. Wadgave U, Nagesh L. Nicotine replacement therapy: an overview. Int J Health Sci. 2016;10(3):425–35. 7. Chaudhary SA, Shahiwala AF. Medicated chewing gum—a potential drug delivery system. Expert Opin Drug Deliv. 2010;7(7):871–85. https://doi.org/10.1517/17425247.2010.493 554. 8. Kvist C, Andersson SB, Fors S, Wennergren B, Berglund J. Apparatus for studying in vitro drug release from medicated chewing gums. Int J Pharm. 1999;189(1):57–65. 9. Jadhav A, Mohite S. A comprehensive review on: medicated chewing gum. Curr Pharm Res. 2014;4(3):1215. 10. Gajendran J. Performance testing of medicated chewing gums with the goal of establishing in vitro in vivo correlation: Universitätsbibliothek Mainz; 2017. 11. Andersen T, Gram-Hansen M, Pedersen M, Rassing MR. Chewing gum as a drug delivery system for nystatin influence of solubilising agents upon the release of water insoluble drugs. Drug Dev Ind Pharm. 1990;16(13):1985–94. https://doi.org/ 10.3109/03639049009023636. 12. Mehta F, Trivedi P. Formulation and texture characterization of medicated chewing gum delivery of dimenhydrinate hydrochloride. Pharm Lett. 2011;2:129–40. 13. Morjaria Y, Irwin WJ, Barnett PX, Chan RS, Conway B. In vitro release of nicotine from chewing gum formulations. Dissolut Technol. 2004;11(2):12–5. 14. Pedersen M, Rassing MR. Miconazole chewing gum as a drug delivery system application of solid dispersion technique and lecithin. Drug Dev Ind Pharm. 1990;16(13):2015–30. https:// doi.org/10.3109/03639049009023638. 15. Stojanov M, Larsen KL. Cetirizine release from cyclodextrin formulated compressed chewing gum. Drug Dev Ind Pharm. 2012;38(9):1061–7. 16. Swamy N, Shilpa P, Abbas Z. Formulation and characterization of medicated chewing gums of dextromethorphan hydrobromide. Indian Drugs. 2012;49(12):29–35. 17. Tyrpin HT, Russell MP, Witkewitz DL, Johnson SS, Ream RL, Corriveau CL. Caffeine coated chewing gum product and process of making. Google Patents; 2002. 18. Woodford D, Lesko L. Relative bioavailability of aspirin gum. J Pharm Sci. 1981;70(12):1341–3. 19. Oliveira CM. Emerging trends in pharmaceutical dosage forms 2015. 20. Witzel F, Mackay DA, Bakal AI, Clark KW. Long-lasting chewing gum and method. Google Patents; 1980. 21. Koch ER, Glass M. Non-stick bubble gum base composition. Google Patents; 1982. 22. Cherukuri SR, Mansukhani G. Reduced calorie chewing gum base and compositions containing the same. Google Patents; 1989. 23. Cherukuri SR, Friello DR, Ferroti M, Jewell W, D’amelia RP. Gum base, chewing gum containing same and method. Google Patents; 1982. 24. Cherukuri SR, Mansukhani G. Reduced calorie chewing gum base and compositions containing the same. Google Patents; 1991. 25. Jacobsen J, Christrup LL, Jensen N-H. Medicated chewing gum. Am J Drug Deliv. 2004;2(2):75–88. 26. Stroz JJ, Bakal AI, Mackay DA. Calorie-free non-adhesive chewing gums and method. Google Patents; 1980. 27. Shin TR. Properties of a model zein-based chewing gum investigated by objective and sensory methods: University of Illinois at Urbana-Champaign; 2008. 28. Athanikar NK, Gubler SA. Process for manufacturing a pharmaceutical chewing gum. Google Patents; 2001. 29. Gubler SA. Process for preparing chewing gum containing a nutritional supplement. Google Patents; 2003. 30. Koch ER, Abbazia LP, Puglia WJ. Process for preparing chewing gum base using solid elastomer. Google Patents; 1980. 31. Merritt CG, Wingerd WH, Keller DJ. Process for preparing a time delayed release flavorant and an improved flavored chewing gum composition. Google Patents; 1983. 32. Mochizuki K, Yokomichi F. Process for the preparation of chewing gum. Google Patents; 1976. 33. Wei YC, Cherukuri SR, Hriscisce F, Piccolo DJ, Bilka KP. Elastomer encapsulation of flavors and sweeteners, long lasting flavored chewing gum compositions based thereon and process of preparation. Google Patents; 1986. 34. FDA U, Food, Administration D. CFR-code of federal regulations title 21. Food and Drug. 2013. 35. Bhowmick AK, Stephens H. Handbook of elastomers: CRC; 2000. 36. Lebedeva NWOV. Polyisobutene-based pressure-sensitive adhesives. Technology of Pressure-Sensitive Adhesives and Products. 2008. 37. Walker J. Elastomer engineering guide. Sheffield: IST; 2012. 38. Potineni RV. Mechanisms of flavor release and perception in sugar-free chewing gum: The Pennsylvania State University; 2007. 39. Fink JK. Reactive polymers: fundamentals and applications: a concise guide to industrial polymers: William Andrew; 2017. 40. Tisdale E, Wilkins C. Method development for compositional analysis of low molecular weight poly (vinyl acetate) by matrixassisted/laser desorption-mass spectrometry and its application to analysis of chewing gum. Anal Chim Acta. 2014;820:92–103. 41. Potineni RV, Peterson DG. Influence of flavor solvent on flavor release and perception in sugar-free chewing gum. J Agric Food Chem. 2008;56(9):3254–9. 42. Yatka RJ, Broderick KB, Song JH, Zibell SE, Record DW. Polyvinyl acetate encapsulation of crystalline sucralose for use in chewing gum. Google Patents; 1992. 43. D’Sa AB, Group IoCP. Adhesives and consolidants in painting conservation: archetype publications; 2012. 44. Khairnar DA, Darekar AB, Saudagar RB. Medicated chewing gum is an excellent drug delivery system for self medication. Asian J Pharm Technol. 2016;6(1):24–30. 45. Hasenhuettl GL, Hartel RW. Food emulsifiers and their applications: Springer; 2008. 46. Gaonkar AG, McPherson A. Ingredient interactions: effects on food quality: CRC; 2016. 47. Weyland M, Hartel RW. Emulsifiers in confectionery. Food emulsifiers and their applications: Springer; 2008. p. 285–305. 48. Dokuzovic Z. Flavor emulsions and chewing gum compositions containing the same. Google Patents; 1988. 49. Mark H. Encyclopedia of polymer science and technology, 15 volume set: Wiley; 2014. 50. Abdel-Malik MM, Vishwanathan A, Orama AM. Non-stick chewing gum base. Google Patents; 2003. 51. Jójárt I. The importance of magnesium stearate in pharmaceutical industry and in the preformulation studies of medicated chewing gums: szte; 2014. 52. Synosky S, Reed MA. Wax-free chewing gum base. Google Patents; 1994. 53. Wessel SW, van der Mei HC, Maitra A, Dodds MW, Busscher HJ. Potential benefits of chewing gum for the delivery of oral therapeutics and its possible role in oral healthcare. Exp Opin Drug Deliv. 2016;13(10):1421–31.