Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2022July25HealthcareStudy the Effects of Standardized Dolichos biflorus Seed Extract and Standardized Pterocarpus marsupium Bark Extract in Blood Coagulation English0104Keshav ChandravanshiEnglish Neelima SahuEnglish Manisha SahuEnglish Preeti PatelEnglish Sweety LanjhiyanaEnglish Anju MishraEnglishKeshav Chandravanshi, Department of Pharmaceutics, School of Pharmacy, Chouksey Engineering College, NH-49, Masturi - Jairamnagar Road, Lalkhadan, Bilaspur 495004, Chhattisgarh, India http://dx.doi.org/10.31782/IJMPS.2022.12701In this study, the antithrombotic activity [antiplatelet, activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) assays] of standardized Dolichos biflorus seed extract (DBSE) and standardized Pterocarpus marsupium bark extract (PMBE) was determined. The study investigated the anticoagulant activities in vitro by performing activated partial thromboplastin time (APTT), prothrombin time (PT), and thrombin time (TT) assays. Antiplatelet aggregation activity of the extract was examined using adenosine diphosphate (ADP), collagen, and thrombin as agonists, and the inhibitions of factor Xa and thrombin were also investigated. Bleeding and clotting times in mice were used to determine its anticoagulant activities in vivo. This study is the first to show that DBSE and PMBE possess anticoagulant properties, most likely as a result of its capacity to block thrombin activity. DBSE and PMBE could be a thrombin inhibitor with anticoagulant therapeutic properties. However, when compared to positive control medications like heparin, argatroban, and dabigatran etexilate, DBSE’s and PMBE’s anticoagulant action is lesser. EnglishExtracts, Blood Coagulation, Antiplatelet, Activated partial thromboplastin time, Prothrombin time, Thrombin timehttp://ijcrr.com/abstract.php?article_id=207http://ijcrr.com/article_html.php?did=2071. RANG, H.P., DALE, M.M., RITTER, J.M. and FLOWER, R.J., 2007. Rang and Dale’s pharmacology. London: Churchill Livingstone, pp. 332-345. 2. BUCH, M.H., PRENDERGAST, B.D. and STOREY, R.F., 2010. Antiplatelet therapy and vascular disease: an update. Therapeutic Advances in Cardiovascular Disease, vol. 4, no. 4, pp. 249-275. 3. PALTA, S., SAROA, R. and PALTA, A., 2014. Overview of the coagulation system. Indian Journal of Anaesthesia, vol. 58, no. 5, pp. 515-523. 4. MEKHFI, H., EL HAOUARI, M., LEGSSYER, A., BNOUHAM, M., AZIZ, M., ATMANI, F., REMMAL, A. and ZIYYAT, A., 2004. Platelet anti-aggregant property of some Moroccan medicinal plants. Journal of Ethnopharmacology, vol. 94, no. 2-3, pp. 317-322. 5. VANE, J.R. and BOTTING, R.M., 2003. The mechanism of action of aspirin. 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Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2022July25HealthcareDevelopment and Characterization of Medicated Ointment Containing Extracts of Dolichos biflorus, Cichorium intybus, Pterocarpus marsupium, and Crataeva nurvala English0509Sandeep KumarEnglish Rewati RamanEnglish Satyendra RathoreEnglish Reenesh JaiswalEnglish Suruchi PrasadEnglishSandeep Kumar, Department of Pharmaceutics, School of Pharmacy, Chouksey Engineering College, NH-49, Masturi - Jairamnagar Road, Lalkhadan, Bilaspur 495004, Chhattisgarh, Indiahttp://dx.doi.org/10.31782/IJMPS.2022.12702The present research reflected towards exploring the plausible role(s) of extracts of Dolichos biflorus (seed), Cichorium intybus (root), Pterocarpus marsupium (bark), and Crataeva nurvala (bark) formulated as ointment product. The formulations were characterized by determining the pharmaceutical characteristics like pH, skin irritancy test, viscosity, appearance, extrudability, spreadability, washability, and swelling index. No specific edema or erythema symptoms were seen following treatment for a continuous seven days according to the skin irritation test investigation. The formulations’ pH levels were determined to be 5.2 (F1) and 5.7 (F2). F1 displayed swelling of 1.29%, whereas F2 displayed swelling of 1.14%. The spreadability of the two ointment formulations (F1 and F2) was 6.9 g.cm/sec and 5.2 g.cm/sec. For F1 and F2, the extrudability of the formulations from the collapsible tubes was determined to be +++ and ++, respectively. The viscosity was determined to be 4550 cps (F1) and 5300 cps (F2) when examining the rheological features of the formulations. The formulations’ washability was determined to be +++ for Formulation-1 and ++ for Formulation-2. 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