Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015November30HealthcareLIVER FUNCTIONS DERANGEMENT AMONG SUBSTANCES ABUSERS
English1926Ekramy ElmorsyEnglish Mohamed Mosad SalamaEnglish Mostafa AbdelsalamEnglish Lucky Legbosi NwiduEnglish Maysaa El Sayed ZakiEnglish Mahmoud El-BendaryEnglish Nahla AnberEnglish Amal Misbah AggourEnglishBackground: Substance abuse is a worldwide problem with rapidly expanding prevalence. Liver is highly vulnerable to xenobiotics toxicities. Methods: We have investigated the effect of substances of 5 commonly abused in Egypt (tramadol, opiates, cannabis, barbiturates and benzodiazepines) on liver functions in persons attending to Mansoura university hospitals. After exclusion of cases with chronic liver diseases, participants were screened by enzyme multiplied immunoassay. Positive cases were confirmed by gas chromatography-mass spectroscopy and examined by abdominal ultrsonography and live functions tests were done. Results: GC-MS showed only 125 positive cases. No abnormalities were detected by ultrasonography in the examined populations. SGOT, SGPT and direct bilirubin were significantly increased, while albumin was significantly decreased in abusers in comparison to nonabusers. Tramadol and other opioids were shown to be the most hepatotoixc agents. In addition, SGOT was shown to be significantly increased to less extent in tramadol and cannabis co-abusers. Furthermore, benzodiazepines were shown to significantly increase serum direct and total bilirubin. Conclusions: We can conclude that tramadol and other opioids significantly alter liver synthetic and excretory function in parallel to significant increase in liver enzymes among abusers. Moreover, cholestatic hepatitis was observed among benzodiazepine abusers.
EnglishHepatotoxicity, Substance abuse, Tramadol abuse, Liver functionshttp://ijcrr.com/abstract.php?article_id=154http://ijcrr.com/article_html.php?did=154Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015November30HealthcareEVOLUTION OF ADHESIVE AND AGGREGATIVE PROPERTIES OF LACTIC ACID BACTERIA, ISOLATED FROM HEALTHY ARMENIAN WOMEN VAGINA
English0104Hrachya G. HovhannisyanEnglish Gohar G. GrigoryanEnglishEnglishVaginal LAB, Adhesion, Coaggregation, Autoaggregationhttp://ijcrr.com/abstract.php?article_id=156http://ijcrr.com/article_html.php?did=156Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015November30HealthcareIMPACT OF A SIMPLE EDUCATIONAL INTERVENTION ON THE KNOWLEDGE AND AWARENESS OF PHARMACOVIGILANCE AMONG MEDICAL UNDERGRADUATE STUDENTS
English0509Liya Roslin JosephEnglish Dhanya Sasidharan PalappallilEnglishObjectives: This study was aimed at investigating the awareness of spontaneous ADR reporting among medical students in a teaching hospital in Kerala, and to analyze the impact of an interventional lecture about pharmacovigilance on the same. Methods: This was a questionnaire based study conducted among 118 medical students at a tertiary care teaching hospital. Each participant was explained the purpose of study and asked to fill in a questionnaire about their knowledge and awareness of pharmacovigilance. All of them attended the lecture on pharmacovigilance and they were allowed to fill the same questionnaire again. Based on the number of correct answers, a scoring had been done. Results: 82% of the participants knew about ADR reporting system in India. Majority of the respondents (88%) knew that, as medical students, they could report ADRs but were unaware about the methodology to report (63.5%). All participants responded that clinicians and medical students should be trained for ADR reporting. Educational intervention had improved their knowledge and awareness significantly which was supported by an increase in mean score from 9.74 to 11.92 (p < 0.001) after the lecture. Majority of them (94.1%) agreed that all sort of ADRs should be reported. Conclusion: Attitude towards ADR reporting was positive but knowledge about ADR reporting system was inadequate among medical students in a teaching hospital in Kerala. The study strongly suggested that there was a need to create awareness about pharmacovigilance among the medical students and awareness programmes should be made an integral part of medical education.
English Pharmacovigilance, Medical students, Awareness, Reportinghttp://ijcrr.com/abstract.php?article_id=160http://ijcrr.com/article_html.php?did=160Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015November30HealthcareEVALUATION OF PARASYMPATHETIC ACTIVITY IN ADULTS WITH DIFFERENT ABO BLOOD GROUPS
English1014Mani Shankar S.English Siva Priya D.V.English Rashmi R.English Jyothi S.English Vinoth Kumar S.English Shyamala ThirumeniEnglishBackground: In gastrointestinal system, parasympathetic tone causes stimulation of all gastric glands and enhances Hydrochloric acid (HCl) secretion which predisposes to peptic ulcer. Aim: To study the role of ABO blood group systems on parasympathetic activity in healthy volunteers. Increased parasympathetic activity in any of these groups will cause increased Hydrochloric acid secretion in gastric juice contributing to increase incidence of peptic ulcer in that group. Methodology: This study was conducted in Department of Physiology, Saveetha Medical college, Chennai. Total of 160 healthy adults of both genders (18-24 years) were included in the study and were divided equally into 4 groups based on their blood groups (ABO system). After obtaining the written consent from the subjects, Heart Rate Variability (HRV) was analysed by frequency domain and time domain methods in all groups using digital physiograph. Results: Statistical analysis done by One way analysis of Variance (One way ANOVA), showed a statistically significant difference (P < 0.001) in HRV parameters among the 4 ABO blood groups. In frequency domain measures, an increase in High frequency HF in normalised Units and decrease in Low frequency (LF) in normalised Units, and the ratio of LF to HF (LF/HF) is decreased in A and O blood groups. In the time domain measures, increase in RR intervals, Standard deviations of all NN intervals (SDNN), Square root of mean of squares of the differences between adjacent NN intervals (RMSSD), Percentage of differences between adjacent NN intervals (pNN50) in A and O compared to B and AB blood group individuals. Conclusion: The present study showed that the A blood group (ABO system) have higher parasympathetic tone when compared to the other blood group systems..
EnglishParasympathetic activity, ABO blood groups, Peptic ulcerhttp://ijcrr.com/abstract.php?article_id=162http://ijcrr.com/article_html.php?did=162Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015November30HealthcareMACULAR AMYLOIDOSIS IN PHOTOEXPOSED AREA: A CLINICAL AND HISTOLOGICAL STUDY
English1518Kirtee MeshramEnglish Milind BorkarEnglish Sushil PandeEnglishEnglish Cutaneous amyloidosis, Cutaneous macular amyloidosis, Actinic macular amyloidosishttp://ijcrr.com/abstract.php?article_id=164http://ijcrr.com/article_html.php?did=164