Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015September30HealthcareEVALUATION OF EFFICACY AND SAFETY OF NUTRICHARGE®S&F (AN NATURAL SUPPLEMENT) ON WEIGHT MAINTENANCE: A RANDOMIZED, PROSPECTIVE, DOUBLE BLIND, PLACEBO CONTROLLED STUDY English1118D.M. RavichandEnglish Rajesh VukkalaEnglish D. Ravishekar ReddyEnglish Kapeel KapoorEnglishEnglishObesity, Metabolic disorder, Nutritional supplementhttp://ijcrr.com/abstract.php?article_id=129http://ijcrr.com/article_html.php?did=129

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015September30HealthcareA PROSPECTIVE COMPARATIVE STUDY OF THE TOXICITY PROFILE IN PATIENTS RECEIVING CISPLATIN-PACLITAXEL VS CARBOPLATIN-PACLITAXEL IN ADVANCED OVARIAN CANCER English0105Susan JosephEnglish Pradeep S.English K.L. JayakumarEnglishThe standard chemotherapy for ovarian cancer includes the combination of paclitaxel and a platinum compound. Comparing carboplatin /paclitaxel with cisplatin/paclitaxel, it has been found that substitution of the analog carboplatin for cisplatin in this combination may improve the toxicity profile. Objectives: 1) To grade toxicity (according to WHO toxicity scale) and to compare the toxicity profile of cisplatin/paclitaxel versus carboplatin/paclitaxel in advanced epithelial ovarian carcinoma. 2) To compare the performance status of patients receiving these regimens. 3) To assess the clinical response rate based on CA 125 criteria. Methodology: 80 patients diagnosed with advanced epithelial ovarian cancer (stage III and stage IV), were recruited for the study and were divided into two groups of 40 each. One group received cisplatin-paclitaxel and the other received carboplatin-paclitaxel. All toxicities were graded according to WHO toxicity grading criteria. Response was assessed by CA 125 criteria, and patients categorized as responders or non responders based on whether raised serum CA 125 (pretreatment) values decreased by 50% during therapy. Results: Hematological toxicity namely anemia, leucopenia and thrombocytopenia were significantly more in patients treated with carboplatin. Nephrotoxicity, ototoxicity, neurotoxicity, nausea, vomiting and diarrhea were significantly more with cisplatin(p value EnglishOvarian cancer, Hematological toxicity, Leucopenia, Thrombocytopeniahttp://ijcrr.com/abstract.php?article_id=151http://ijcrr.com/article_html.php?did=151

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-5241EnglishN2015September30HealthcarePREVALENCE OF NASAL CARRIAGE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) AND ITS ANTIBIOTIC SUSCEPTIBILITY PATTERN IN HOSPITAL PERSONNEL IN A TERTIARY CARE CENTRE IN WESTERN INDIA English0610Nirmal M. ChanneEnglish Pradnya S. GajbhiyeEnglish Jyoti A. IravaneEnglish Ajit S. DamleEnglishAim: Methicillin resistant Staphylococcus aureus (MRSA) in hospital is troublesome. Healthcare workers (HCWs) can act as reservoir and may result in its spread to susceptible patients. The present study estimates the prevalence of staphylococcal and MRSA carriages among HCWs as well as the susceptibility pattern of these strains against other selected antibiotics. Methodology: A total of 94 health care personnel from surgery wards and operation theatres were screened for MRSA carriage by taking anterior nasal swab. MeReSa chromogenic agar was used as a screening method. Minimum inhibitory concentration (MIC) determination by Agar dilution technique was used as a confirmatory method. Antibiotic susceptibility testing (AST) was done for the selected antibiotics. Results: Samples of 94 HCWs were screened. S.aureus carriage was found out to be 70 % (66/94). MRSA carriage was found to be 27 % (25/94) by screening MeReSa chromogenic agar (bluish green colonies), whereas it was 19 % (18/94) by oxacillin Agar dilution MIC method. 11% of MRSA strains were intermediate sensitive (IS) to vancomycin. All the strains were sensitive to linezolide, tigecycline and vancomycin. Conclusions: Significant prevalence of nasal carriage of MRSA and S. aureus among HCWs was found. Chromogenic agar can be used as a screening method of MRSA carriage and MIC by agar dilution can be used as a confirmatory method. Multi-drug resistance was prevalent in both MRSA and MSSA strains which is a worrisome fact. English MRSA, MSSA, MeReSa agar, Healthcare workers, Agar dilution MIChttp://ijcrr.com/abstract.php?article_id=161http://ijcrr.com/article_html.php?did=161