Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410406EnglishN2014February28HealthcareTHE HEPATOPROTECTIVE EFFECT OF HIBISCUS ROSA SINENSIS FLOWER EXTRACT ON DIET - INDUCED HYPERCHOLESTEROLEMIA IN MALE ALBINO WISTAR RATS English0110Anupam BiswasEnglish Urban J.A. D’SouzaEnglish Shankar BhatEnglish Damodar D.EnglishBackground: Hypercholesterolemia is associated with to coronary heart disease (CHD) which is the principal cause of morbidity and mortality worldwide. Over the last few decades the reputation of herbal remedies has increased globally due to its therapeutic efficacy and safety. Aim: This study was carried out to investigate the hepatoprotective potential of locally grown Hibiscus rosa sinensis flower extracts in diet induced hypercholesterolaemic rat hepatocytes. Methodology: Male Wistar rats (180-230gm) were divided into seven groups of six animals each (n=6). The first group served as the control. All the animals were induced hypercholesterolemia by feeding pure cholesterol and cholic acid orally mixing with coconut oil with 2:1 ratio for 4 weeks. Three groups were given HRS flower extracts orally, at doses of 80mg / kg, 160mg / kg and 240 mg / kg body weight once a day for 5 days (acute) and another three groups were given same doses of HRS flower extracts for 30 days (chronic). At the end of treatment duration all animals were sacrificed by cervical dislocation. Laparotomy was performed. Blood was collected by cardiac puncture and allowed to clot. Serum was separated for the estimation of lipid profile, liver enzymes, total protein, albumin levels and plasma were used to estimate the MDA levels. Atherogenic Index (AI) was calculated. Results: There was increase in body weight in cholesterol fed experimental animals which was reversed with HRS fed groups. There was a dose dependent increase in serum hepatic marker enzymes and total protein levels significantly (p>0.001) in the cholesterol fed groups and reversed with HRS flower extract fed acute (p>0.005) and chronic (p>0.001) groups. Increase in blood MDA level were seen in hypercholesterolaemic groups and significantly reduced (p>0.05) in HRS flower extract treated animals. Conclusion: The present study suggests that HRS flower extract could play a hepatoprotective role against hypercholesterolemia through the regulation of cholesterol levels and inhibition of lipid peroxidation. EnglishHibiscus rosa sinensis, cholesterol, atherogenic index, coronary heart disease, hepatic markers, lipid per oxidation.http://ijcrr.com/abstract.php?article_id=78http://ijcrr.com/article_html.php?did=78

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410406EnglishN2014February28HealthcareLEVEL OF ADHERENCE AND CLUSTER OF DIFFERENTIATION 4 CELLS RESPONSE: A STUDY ON PATIENTS LIVING WITH HIV / AIDS AT TERTIARY CARE HOSPITAL, CENTRAL KARNATAKA English1118Aswin KumarEnglish Girish H.O.English Raghavendraswamy KoppadEnglish Balu P. S.English Vijayakumar B.EnglishBackground: A major concern with scaling up of antiretroviral treatment in resource limited settings is the emergence of drug resistant viral strains due to sub optimal adherence. CD4 count is also used as proxy measure to assess the level of adherence. Objectives: To study the level of adherence and to know the CD4 response in relation to adherence. Methods: A cross-sectional, observational study conducted using a semi structured and pre-tested questionnaire on 270 PLHA receiving ART. PLHA were interviewed from 1st Dec 2008 to 31st Jan 2010, at an integrated positive prevention clinic at tertiary care hospital. Adherence was assessed on self report over a period of 3 months. CD4 count was taken from the records Statistical analysis: Proportions, Chi-square test, z test using Microsoft excel Results: The mean age for PLHA was 36 years. Majority were females (55%). 79% (213) were adherent over previous one week recall and 84% (227) were adherent over previous 4 days. Adherence increased over longer period of recall. The mean CD 4 count of adherent group was 438.8 cells/mm3 and that of non adherent group was 332.3 cells/mm3 , the difference was statistically significant. Mean change in the CD4 count was increased as the duration of treatment with ART increased in adherent group. Conclusion: Level of adherence found was low hence adherence issues should be addressed during counseling of PLHA. Study indicates that better adherence leads to better immunological outcome. EnglishAdherence, CD4 count, antiretroviral therapy, HIV, AIDShttp://ijcrr.com/abstract.php?article_id=91http://ijcrr.com/article_html.php?did=91

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410406EnglishN2014February28HealthcareCARDIOVASCULAR RESPONSES TO AUTONOMIC STRESSORS IN YOUNG ADULTS BELONGING TO HYPERTENSIVE FAMILY English1925Lata GuptaEnglish Dharmendra DodiyaEnglish Vanita PanchalEnglish Dipti JainEnglish Beena GoyalEnglishHypertension is a burning health problem in modern world, full of worries and anxieties. Subjects at high risk of future hypertension are either the persons belonging to hypertensive family or having high resting heart rate. Purpose: To investigate whether normotensive young adults with family history of hypertension demonstrate exaggerated cardiovascular responses to autonomic stressors as compared to normotensive young adults without family history of hypertension. Research Methodology: 32 Subjects, age between 18 to 20 years belonging to hypertensive family were selected as case and another 32 subjects, age between 18 to 20 years were selected as control from non hypertensive family. Resting Heart Rate (HR) and Mean Blood Pressure (MBP) were recorded and found normal. Blood Pressure (BP) was recorded by Mercury Sphygmomanometer. Changes in HR and MBP induced by autonomic stressors like Cold Pressure Test and Valsalva Manoeuvre were recorded during the test and in recovery phase. Results: By giving autonomic stressors significant increase in HR and MBP was observed in both the groups. But response to autonomic stressors is significantly higher in subjects belonging to hypertensive family. Conclusion: Our results shows that, subjects belonging to hypertensive families are found to be more reactive towards physical stimuli. These young adults are more prone for hypertension in future as compared to subjects belonging to normotensive families. Early detection of proneness to hypertension may help an individual to lead a healthy life by altering the life style (by diet restriction, exercise etc.). EnglishAutonomic Response, Autonomic Stressors, Cold Pressure Test, Hypertension, Valsalva Manoeuvrehttp://ijcrr.com/abstract.php?article_id=100http://ijcrr.com/article_html.php?did=100

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410406EnglishN2014February28HealthcareEFFECT OF DURATION OF TYPE 2 DIABETES ON SHORT TERM AND WORKING MEMORY     English2630Sanjay B. BhagojiEnglish Mahesh PatilEnglish Mrutyanjay MirjeEnglish ShivaprasadEnglishBackground and objectives: Working and short term memory loss is common in elderly and poorly controlled diabetic patients. Though cognitive deficits affect daily activities much importance is not given to assess working and short term memory at bedside. Hence this study was undertaken to compare working and short term memory in type 2 diabetics to correlate with duration. Materials and methods: Present study was conducted in Al-Ameen Medical College and Government district Hospital, Bijapur on 114 diabetics (40-60 yrs). Cognitive function assessment was done for short term and working memory by using 5 memory tests. For short term memory- AVLT, VFT and VRT and for working memory – WDST and VST were used. The results were expressed in average total scores (%). one way ANOVA followed by post hoc “t” test and correlation- regression analysis were used for statistical analysis. Results: Short term and working memory status was negatively correlated with duration of the diabetes. Among diabetics elderly aged (> 55yrs) showed greater cognitive decline compared to younger age group. Conclusion: The short term and working memory status in the present study decreased significantly in the diabetic patients, which may be due to hyperglycemia, hypoglycemia, vascular dementia and insulin resistance, amyloid deposition, type of diabetes, co morbidities, age of onset, duration and type of therapy. Therefore these observed effects of duration, age, gender and blood glucose levels are of potential clinical importance because working and short term memory loss could interfere with day today activities. English short term and working memory, Diabetes, hyperglycemia, hypoglycemiahttp://ijcrr.com/abstract.php?article_id=108http://ijcrr.com/article_html.php?did=108

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410406EnglishN2014February28HealthcareEVALUATION AND COMPARATIVE STUDY OF HYPOGLYCEMIC ACTIVITY OF ALOE BARBADENSIS MILLER WITH ORAL HYPOGLYCEMIC DRUGS (GLIBENCLAMIDE AND METFORMIN) IN RATS English3136Shinde V.S.English Borkar A.S.English Badwaik R.T.EnglishBackground: Aloe barbadensis miller (commonly known as Aloe vera) is widely used in traditional medicine. The leaf gel of Aloe barbadensis miller has shown hypoglycemic activity in Alloxan and STZ induced diabetic rats. There are few controversial reports which do not support its hypoglycemic activity. The present study was designed to compare the anti hyperglycemic activity of ethanolic extract of fresh leaf gel of Aloe barbadensis miller with standard glibenclamide and metformin in Streptozotocin induced diabetic rats. Materials and Methods: Albino rats were divided into six groups of six animals each. In five groups diabetes was induced by using streptozotocin (50 mg/kg i.p.). Group I – Normal control; Group II - Diabetic control; Group III – Diabetic + glibenclamide (5mg/kg); Group IV – Diabetic + metformin (10mg/kg); Group V – Diabetic + Aloe barbadensis miller fresh leaf gel ethanolic extract (300mg/kg); Group VI – Diabetic + Aloe barbadensis miller fresh leaf gel ethanolic extract (500mg/kg). All drugs were given once daily. Blood glucose was estimated from rat tail vein using glucometer before start of experiment and on day 1, 3, 7, 21, 28, 35 and at the end of 42 days. Oral glucose tolerance test (3gm/kg) was performed after 42 days in each group. Results: Fresh leaf gel ethanolic extract of Aloe barbadensis miller produced significant reduction in fasting blood glucose levels in both test groups. At the end of 42 days mean reduction in fasting blood glucose level was 44% and 73% in Group V (300mg/kg) and Group VI (500mg/kg) respectively. Conclusion: The result of present study indicates that Aloe barbadensis miller has significant hypoglycemic effect as compared to standard drug glibenclamide and metformin in STZ induced diabetic rats. EnglishAloe vera, Streptozotocin, Diabetes, Aloe barbadensis miller.http://ijcrr.com/abstract.php?article_id=113http://ijcrr.com/article_html.php?did=113