Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410408EnglishN2013December28HealthcareADVERSE EFFECTS OF ZIDOVUDINE ON RAT'S VISION: ANTIOXIDANT AND ENZYMOLOGY PERSPECTIVES English0109Patrick Sunday IgbigbiEnglish Josiah Obaghwarhievwo AdjeneEnglish Ezekiel Uba NwoseEnglishBackground: The biochemical effects of chronic administration of Zidovudine on intracranial auditory relay centre of adult Wistar rats has been studied and reported. The objective of this related study is to investigate how the oxidative stress and antioxidant enzymes biomarkers in the tissues of intracranial visual relay centre of zidovudine-treated group compare with non-treated group. Materials and Methods: As in the study on auditory functions, the rats of both sexes (N=40), with an average weight of 200g were randomly assigned into treatment (n1=20) and control (n2=20) groups. The rats in the treatment group received 300mg/70kg (0.857mg/200g) body weight of zidovudine being the dosages required twice daily dissolved in distilled water daily and given for thirty days through orogastric tube administration While the control rats received equal volume of distilled water through the same route and for the same period. Catalase, glucose-6-phosphate dehydrogenase, glutathione peroxidase, lactate dehydrogenase and superoxide dismutase; as well as malondialdehyde were tested in the superior colliculus and lateral geniculate body tissues. Results: Malondialdehyde as a non-enzyme biomarker of oxidative stress as well as glutathione peroxidase and superoxide dismutase activities are higher on the treated superior colliculus, but lower in lateral geniculate body, with statistical significant (PEnglishlateral geniculate body, biochemical effects, superior colliculus, vision, Zidovudinehttp://ijcrr.com/abstract.php?article_id=76http://ijcrr.com/article_html.php?did=76

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410408EnglishN2014April30HealthcareA RARE CASE OF INTRAMUSCULAR MYXOMA MIMICKING NERVE SHEATH MYXOMA English1014Vidyadhara Rani P.English Naveen Kumar S.EnglishIntramuscular myxoma is a rare, benign lesion of mesenchymal origin, affecting the skeletal muscles. They have an incidence of around 0.1–0.13 cases per 100000 people. We report the case of a 55-year-old woman presenting with a mass of the postero-medial aspect of upper part of right thigh. On fine needle aspiration cytology it was interpreted as a neurofibromatous lesion. She underwent marginal excision. The pathological examination revealed the diagnosis of intramuscular myxoma. EnglishIntramuscular myxoma, mimicking nerve sheath myxoma.http://ijcrr.com/abstract.php?article_id=87http://ijcrr.com/article_html.php?did=87