Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410402EnglishN2013October30HealthcareSTRUCTURAL DAMAGE IN THE NECK STRUCTURES DUE TO HANGING
English0105Dharmaraya IngaleEnglish Rekha HiremathEnglish Anand MugadlimathEnglish M. A. Bagali English Manjunath K. H.English ThirunavukkarasuEnglishEnglishHanging, strangulation, injury to neck structures, hyoidbone.http://ijcrr.com/abstract.php?article_id=71http://ijcrr.com/article_html.php?did=71Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410402EnglishN2013October30HealthcareIN VITRO PENETRATION OF THE ANTIBIOTIC FOSFOMYCIN IN SWINE INTESTINAL CELLS (IPEC J2)
English0616D.S. PèrezEnglish G. Martínez English A.L. SoraciEnglish M.O. TapiaEnglishFosfomycin is an antibiotic widely used for the treatment and prevention of swine infections caused by resistant bacteria. The aim of this research was to study the penetration of fosfomycin in an in vitro model of intestinal cells (IPEC-J2 cells). Cells cultures were subjected to 580 µg/mL of calcium fosfomycin. Intracellular concentrations of the antibiotic were analyzed by HPLC MS/MS and they ranged from 23.48 to 45.81 µg/mL (Tmax: 4 h). Fosfomycin concentrations exceeded the MIC90 for the most important pathogens in swine intestinal infections (Escherichia coli: 0.50 µg/mL, Salmonella enterica subsp. Enterica: 4 µg/mL). Therefore, it is apparent that fosfomycin is an alternative for the treatment of intestinal infections in pigs.
EnglishFosfomycin, in vitro, penetration, IPEC -2 cells, intestinal infections, pigshttp://ijcrr.com/abstract.php?article_id=82http://ijcrr.com/article_html.php?did=82Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410402EnglishN2013October30HealthcareA COMPARATIVE EVALUATION OF CYTOTOXICITY OF FOUR DIFFERENT ANTIOXIDANTS: AN IN VITRO STUDY
English1724Ghada M. SuddekEnglish Nadia M. MaysaraEnglishApigenin, allicin, chrysin and sulforaphane were investigated for their comparative cytotoxic abilities in vitro against four human cancer cell lines: HePG-2 hepatocellular carcinoma, MCF-7 breast cancer cells, HeP-2 laryngeal carcinoma and HCT-116 colorectal carcinoma. In vitro cytotoxicity was evaluated by MTT assay. These antioxidants, especially apigenin and allicin exhibited potent cytotoxic effects on the four tested tumor cell lines.
EnglishApigenin, Allicin, Chrysin, Sulforaphane, tumor cells, cytotoxic activity.http://ijcrr.com/abstract.php?article_id=97http://ijcrr.com/article_html.php?did=97Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410402EnglishN2013October30HealthcareEFFECT OF POLOXAMER 407 ON THE SERUM CHOLESTEROL AND TRIGLYCERIDE OF RABBITS
English2529Harish Govind NaikEnglish Dundesh Y. MaledEnglish Chitra C. KhanwelkarEnglish Vandana M. ThoratEnglish Sujata A. JadhavEnglish Ashwini KolurEnglishObjective: To study the effect of Poloxamer 407 on rabbit’s serum Cholesterol and Triglycerides following intravenous injection. Materials and Methods: Poloxamer 407 is used in parenteral formulations as solubilizing and wetting agents for traditional, low-molecular weight organic drug molecules and as stabilizing agents for proteins and polypeptide drugs. Intravenous injection of poloxamer 407 was evaluated for the effect on the rabbit’s serum cholesterol and triglyceride. Pretreatment, baseline readings were recorded. Rabbits were injected with 5.5mg/kg, 27.5 mg/kg and 137.5 mg/kg and its effect on blood chemistry were assessed at 2nd , 4 th and 7th day. The results of the study were expressed as mean±S.E and data was analyzed by using by one way analysis of variance test (ANOVA). Values with P < 0.05 were considered as significant. Result: The highest dose of Poloxamer 407 (137.5 mg/kg) significantly increased serum triglycerides in rabbits with the maximum increase observed at 2 d after injection. All the doses did not alter the serum cholesterol level. The lower doses of P-407 did not alter serum triglycerides or cholesterol significantly. Conclusion: Our result demonstrated that Poloxamer 407 in higher dose significantly increased serum triglycerides but low doses of this polymer may be used without the untoward hyperlipidemic effect.
EnglishPoloxamer 407, Cholesterol, Triglycerides, Rabbit.http://ijcrr.com/abstract.php?article_id=105http://ijcrr.com/article_html.php?did=105Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410402EnglishN2013October30HealthcareFERRITINEMIA IN BREAST CARCINOMA PATIENTS: IRON-A POSSIBLE RISK FACTO
English3036Narkhede Harshal P. English Muddeshwar Manohar G.English Apte Indrayani C.English Ghangale Suresh S.English Shende Shilpa S.English Chakole Sunil A.EnglishBackground- Reactive oxygen species (ROS) mediated cellular damage has been a very well known mechanism of cancer. Haber-Weiss and Fenton reactions depict iron-mediated (Fe2+/Fe3+) production of ROS and hydroxyl radicals. Enhanced ROS synthesis via redox cycling of oestrogen metabolites, superadded by action of iron has been a proposed mechanism of oestrogen induced carcinogenesis. Objective and Methodology- Pertaining to these facts, serum ferritin (storage iron) was analysed in 50 cases of breast cancer and 50 healthy subjects by Enzyme linked Immuno-Sorbent Assay to assess aberrations in its concentrations in serum. Result- The present study revealed highly significant rise in serum ferritin levels in breast carcinoma patients than in controls [PEnglishFerritin, Breast cancer, Oestrogen-induced carcinogenesis, Iron, ROShttp://ijcrr.com/abstract.php?article_id=112http://ijcrr.com/article_html.php?did=112Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410402EnglishN2013October30HealthcareEVALUATION OF PROLONGED QT INTERVAL AMONG UNCOMPLICATED OBESE YOUNG MALES
English3743Subhashree RayEnglish Ellora DeviEnglish Samir SahuEnglish E. Venkata RaoEnglishIntroduction: WHO reports overweight and obesity as the fifth leading risk factor for global deaths. Obesed subjects are more prone to ventricular arrthymias and sudden death. Aim of the study-We evaluated the interval b/w Q & T waves (QT interval) in a 12 lead electrocardiogram among obese young males without comorbidities. Research Methods and Procedure: The study comprised of 111 young males grouped into 51 obese subjects and 60 healthy controls depending upon their BMI and WC in accordance with NIH guidelines. The QT interval was recorded by 12 –lead ECG, measured manually & corrected according to Bazett’s formula. Exclusion criteria-The study group selected were healthy young males who had no diabetes, hypertension, cardiovascular disease, psychiatric problems & h/o of alcohol abuse. Result: In the present study, the mean QTc values for control groups were within the normal range(QTc-422.9±27.6 ms) and for cases QTc was (443.4±20.48 ms) which was found to be significantly prolonged(pEnglishUncomplicated obesity, QTc, BMI, Waist circumference.http://ijcrr.com/abstract.php?article_id=116http://ijcrr.com/article_html.php?did=116