Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410104EnglishN2011June30HealthcareENHANCED DISSOLUTION AND BIOAVAILABILITY OF GRANISETRON HYDROCHLORIDE BY DIRECT COMPRESSION TECHNIQUE English0109Basawaraj S.PatilEnglish N.G.Raghavendra RaoEnglishIn the present study, an attempt had been made to prepare fast dissolving tablets of the drug using, plantago ovata mucilage and sodium starch glycolate as super disintegrants (2.5 to 10 % w/w) following by direct compression method. Formulations were evaluated for precompressional parameters such as angle of repose, carr’s compressibility index and hausner’s ratio. The tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, wetting time, in-vitro dispersion time and in-vitro dissolution study. Compare to sodium starch glycolate formulations, plantago ovata formulations shows faster release of drug, this is due to more swelling property of plantago ovata mucilage. In case of formulation GPO4, the 50% and 90% of drug release was found within 0.42 and 2.51min.The compatibility of drug with other ingredients was checked by FTIR studies, the results revealed that there was no interaction between dug and other excipients. EnglishFast dissolving tablet, Granisetron hydrochloride, Plantago ovata mucilage, Sodium starch glycolate, superdisintegrants.http://ijcrr.com/abstract.php?article_id=4http://ijcrr.com/article_html.php?did=4

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410104EnglishN2011June30HealthcareTO STUDY THE STATUS OF ANAEMIA IN YOUNG FEMALE POPULATION OF AURANGABAD REGION English1016 Priyanka WankhadeEnglish Prafulla ManeEnglish Kavita AtreEnglish Rahul MayeeEnglishObjective: Female adolescents and adults are among the population groups who are most affected by iron deficiency. This study was designed investigate the prevalence of anaemia, a common low haemoglobin condition, in young female population of Aurangabad region (MS). On an average the haemoglobin level in female should be within the range of 12.1 to 15.1g/dL. But, given the modern lifestyle, dietary intakes, altered food habits etc. occurrence of anemia is becoming more and more common in young women. Methods : 108 female college students participated in the study. The haemoglobin (Hb), level was measured using Sahli’s haemoglobinometer. Anaemia was defined as a situation where Hb is less than 12 g/dL. Further the anaemia was categorized into severe, moderate and mild based on the Hb levels. Results: The complete data was available for 108 young female students of Aurangabad region (MS). The prevalence of anaemia was 83.34 percent. Normal haemoglobin status was found in 16.66 percent of the subjects. Conclusion: Anaemia is common among 18 to 25-year old females of Aurangabad region (MS). Iron supplementation is thus required for the target group. English Haemoglobin, Anaemia, young females.http://ijcrr.com/abstract.php?article_id=5http://ijcrr.com/article_html.php?did=5

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410104EnglishN2011June30HealthcareDESIGN AND EVALUATION OF DRUG RELEASE KINETICS OF DILTIAZEM HYDROCHLORIDE SUSTAINED RELEASE TABLETS English1729Ramakrishna.S English Mihira.VEnglish K.TabithaEnglishObjective: The main objective of this work is formulation development of Diltiazem Hydrochloride sustained release tablets and to understand the kinetics of drug release by applying mathematical and model-dependent approaches. Methods: Six formulations of sustained release tablets were prepared by the direct compression method using Starch-Urea-Borate Polymer (10%, 20%, 33% and 50%), Ethyl Cellulose, HPMC 4000cps and Guar Gum as polymers. The in-vitro drug release was studied in pH 1.2 HCl and 7.4 pH phosphate buffer using USP dissolution Apparatus 2 at 100 rpm. Zero-order, first-order, Higuchi, Hixson-Crowell and Korsmeyer et al. models were used to estimate the kinetics of drug release. Results: Drug release kinetics indicated that the drug release was best explained by Higuchi’s equation, as these plots showed the highest linearity (R 2 = 0.9902) indicating the release of drug from matrix as a square root of time dependent process. Korsmeyer’s plots indicated an n value of 0.465, which was indicative of an anomalous diffusion mechanism or diffusion coupled with erosion; hence, the drug release was controlled by more than one process. Hixson-Crowell plots indicated a change in surface area and diameter of the tablets with the progressive dissolution of the matrix as a function of time. Conclusion: Drug release from the optimal batch was explained by the Higuchi model. The difference in percent cumulative drug release of each point was highest for the optimum batch. Englishhttp://ijcrr.com/abstract.php?article_id=6http://ijcrr.com/article_html.php?did=6