Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410203EnglishN2012May25HealthcareCARDIOPROTECTIVE EFFECT OF PONGAMIA PINNATA HYDRO-ALCOHOLIC LEAF EXTRACT AGAINST ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION IN WISTAR ALBINO RATS
English0115Behera SaiprasannaEnglish S. Manohar BabuEnglish Y. Roja RamaniEnglish Choudhury Prasanta KumarEnglish Panigrahi RajeshreeEnglishThe present study was designed to examine the phyto-constituents and cardioprotective activity of Pongamia pinnata (PP) leaf extract (hydro-alcoholic) in experimentally induced myocardial infarction in Wistar Albino rats. Six groups of Wistar albino rats, each comprising six animals, were selected for this study. Group I served as a control, Group II rats were given isoproterenol (20 mg/100g, subcutaneously), and Group III rats were given Pongamia pinnata leaf extract (300 mg/kg). Groups IV, V and VI rats were given Pongamia pinnata leaf extract (100 mg/kg, 200 mg/kg and 300 mg/kg, respectively) and isoproterenol (20 mg/100g subcutaneously) prior to MI induction. The transaminases (aspartate transaminase and alanine transaminase), lactate dehydrogenase (LDH) and creatine phosphokinase (CK), were estimated in both the plasma and heart tissues. Troponin T activity was separately estimated for plasma. Isoproterenol significantly increased the activities of CK, LDH and the transaminases in plasma with a concomitant decrease in these enzymes in tissue. Pretreatment with the hydro-alcoholic leaf extract of Pongamia pinnata at a dose of 300 mg/kg body weight for 30 days had a significant effect on the activities of marker enzymes compared to the other groups. Pongamia pinnata pretreatment may offer protection in experimental cardiotoxicity induced by isoproterenol. Phytochemical screening of the plant leaves reveals the presence of carbohydrates, alkaloids, flavonoids glycosides, steroids, tannins and saponins.
EnglishPongamia pinnata, hydro-alcoholic leaf extract, cardio protective, isoproterenol, cardiac markers.http://ijcrr.com/abstract.php?article_id=53http://ijcrr.com/article_html.php?did=53Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410203EnglishN2012May28HealthcareCONVENTIONAL AND NEWER ORAL IRON PREPARATIONS
English1622Sunita S. PatilChitra C.KhanwelkarEnglish Sunil.K. PatilEnglishIron deficiency anaemia is a major health problem world wide. In India, prevalence of anaemia is very high. Oral iron therapy is the commonest treatment of this disease .Large number of iron salts is available in market for oral iron therapy. In clinical practice oral iron supplementation commonly used are Fe sulfate, Fe fumarate. These conventional iron preparations have more gastrointestinal intolerance but are cheap. There are many new iron salts marketed (Fe bisglycinate, Carbonyl iron, Iron polymaltose complex etc) which claim to have low gastrointestinal intolerance, increase Hb level faster and improve iron stores better than conventionally used iron salts. This review is aimed towards collection of information about conventional and newer oral iron preparations. Literature search is done by using internet, text books of Pharmacology and Medicine and Journals available in medical college library. The newer preparations do have less side effects, but are very costly and there are many studies which shows controversy with these newer preparations, which should be further evaluated. Thus conventional iron preparations still can be considered as best cost effective choice with tolerable side effects for prophylaxis and treatment of iron deficiency anaemia.
Englishferrous fumarate, ferrous bisglycinate, carbonyl iron, iron polymaltose complex.http://ijcrr.com/abstract.php?article_id=54http://ijcrr.com/article_html.php?did=54