Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareFINE NEEDLE ASPIRATION CYTOLOGY OF SALIVARY GLAND LESIONS: A STUDY OF 70 CASES English0110Chetna JainEnglishBackground of study: Fine-needle aspiration cytology (FNAC) is initial diagnostic tool to diagnose any swelling in major salivary glands and some minor salivary glands. Superficial location of salivary glands makes them most favorable target for FNAC. Aim: The aim of this study was to evaluate the overall advantages of FANC as compared to formal biopsy with respect to hospitalization, cost-effectiveness, speed. Research Methodology: FNAC were carried out on 70 patients who were suffering from the salivary gland lesions from January-2000 to December-2001. Histopathological follow-up data were acquired in 30 cases. The study was carried out to observe the sensitivity, specificity, and accuracy of FNAC for salivary gland lesions in comparison with histopathology. Results: The male-to-female ratio was 1.5:1. Parotid gland was involved in 54.28%, submandibular gland in 44.28% and other minor salivary glands in 1.42% of patients. There were 54.27 % cases of non-neoplastic lesions and 45.31% cases of neoplastic lesions on biopsy. Sensitivity, specificity, positive predictive value, and negative predictive value of FNAC for malignant neoplastic lesions were 92.3%, 100%, 100%, and 93.3%, respectively, whereas for benign neoplastic lesions, they were 93.3%, 100%, 100 %, and 92.3%, respectively. Conclusion: Fine-needle aspiration cytology is a very useful diagnostic tool for superficial palpable tumors as salivary glands. It is the safe, simple, minimally invasive with low-cost routine office procedure. Delay in diagnosis with conventional histopathological method is overcome and this would allow us prompt further management. EnglishFine-needle aspiration cytology, salivary gland lesions, Histopathology, sensitivity, specificity.http://ijcrr.com/abstract.php?article_id=16http://ijcrr.com/article_html.php?did=16

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareTRABECTEDIN-RELATED MUSCULAR AND OTHER ADVERSE EFFECTS; DATA FROM PUBLIC VERSION OF THE FDA ADVERSE EVENT REPORTING SYSTEM English1117Swathi MallaEnglish Sahaja BandaEnglish Dipika BansalEnglish Kapil GudalaEnglishEnglishAdverse events, Data mining, Trabectedin.http://ijcrr.com/abstract.php?article_id=28http://ijcrr.com/article_html.php?did=28

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareDETERMINATION OF LEVOFLOXACIN IN SOME COMMERCIAL ORAL FORMULATIONS BY USING SPECTROPHOTOMETER AND HPLC English1419Badwaik R.T.English Dashputra A.V.English Gupta M.EnglishObjectives: Levofloxacin is pure (-)-(S)-enantiomer of the racemic drug substance ofloxacin, which was introduced in 1997. It is a third generation fluoroquinolones with a wide spectrum of action against gram-positive and gram-negative bacteria, anaerobic microorganisms and atypical pathogens. Various analytical methods have been reported in scientific literature for the analysis of levofloxacin in pharmaceutical formulations. The price of different oral formulations of levofloxacin varies considerably. Generic tablets are cheaper than branded ones. In order to assure the bioequivalence and therapeutic equivalence, pharmaceutical equivalence study needs to be investigated and hence the present study was undertaken to compare the pharmaceutical equivalence of the generic and some branded oral formulations of levofloxacin and to compare the findings of spectrophotometer and high performance liquid chromatography (HPLC). Methods: Levofloxacin was estimated by using UV spectrophotometer. Linearity curve was obtained in the concentration range of 2-12µg/ml at 293.7 nm using pure levofloxacin and 0.1 N HCl as a solvent system. The concentration in various formulations was obtained by using calibration curve. The quantitative measurements were also obtained by HPLC at 293 nm by using mobile phase consisting of 0.05M phosphate buffer: acetonitrile (80:20, v/v) with 0.2% of triethylamine and pH adjusted to 3 with phosphoric acid. Results: All formulations were found to be pharmaceutically equivalent. The spectrophotometric method was comparable to HPLC. Conclusion: Being simple, rapid, reliable and cost-effective spectrophotometer method can be applied for routine analysis of levofloxacin and for pharmacokinetic study. EnglishLevofloxacin, Spectrophotometer, HPLChttp://ijcrr.com/abstract.php?article_id=29http://ijcrr.com/article_html.php?did=29

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareHYPOTHYROIDISM: ITS SCREENING AND MANAGEMENT AND ROLE IN ERYTHROCYTE ABNORM+ALITIES: A SYSTEMATIC REVIEW English1825Haamid BashirEnglish Mohammad Hayat BhatEnglish Sheikh ShoibEnglish Rabia FarooqEnglish Rabia HamidEnglish Sabhiya MajidEnglishHaematological parameters show substantial variability in different ethnic populations, in which predisposition to anemia is a major factor. Findings in patients with subclinical hypothyroidism and primary hypothyroidism illustrates that even minor alterations in serum thyroid function tests can have important consequences for a variety of thyroid hormone-related clinical endpoints. In the last few years, several studies described variations in hematological parameters in hypothyroidism-a type of thyroid dysfunction, where Hb, MCV, RDW, HCT and RBC: a several hematological indices have shown substantial increases than normal reference range in this disorder and have correlation with minor alteration of serum thyroid hormones. In this review, we discuss the variations in hematological parameters in hypothyroidism and its management. We discuss the possible consequences of these studies for the patients and also new insight in thyroid hormone action and haematology from these data. We have also touched about the screening of thyroid profile and haematological parameters,an important information to general public for clinical and diagnostic use. EnglishHaematological parameters, Screening, thyroid hormones and hypothyroidism.http://ijcrr.com/abstract.php?article_id=35http://ijcrr.com/article_html.php?did=35

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareCAN HYPONATRAEMIA PREDICT MORTALITY IN INTENSIVE CARE UNIT PATIENTS: A PROSPECTIVE STUDY IN A TERTIARY CARE HOSPITAL OF KOLKATA English2630Ranadip ChowdhuryEnglish Tanmay SamantaEnglish Koushik PanEnglish Anup SarkarEnglish Subrata ChakrabartiEnglishBackground of study: Hyponatraemia is a commonly encountered plasma electrolyte abnormality. As aggressive or inappropriate therapy of hyponatraemia can be more harmful than the condition itself, clinicians should be familiar with the diagnosis and management of various forms of hyponatraemia. Objective: To assess the socio-clinical profile of the patients admitted in the Intensive care unit with hyponatraemia & to assess predictors of mortality in the study population Research Methodology: This prospective observational study was done in the Intensive care unit of SSKM Hospital / IPGME&R, Kolkata during April 2011 to March 2012 among the patients having serum sodium level less than135 mmol/l. The data were collected on predesigned questionnaires which include age, gender, clinical findings, complications and laboratory tests. SPSS 16.0 version was used for statistical analysis Results: Males are more commonly affected than females. Chronic liver disease is most common underlying condition associated with hyponatraemia. On multivariate logistic regression analysis serum sodium was found to be statistically significant predictor for mortality (as p value < 0.05). Conclusion: Hyponatraemia could predict the mortality in intensive care unit patients, so proper emphasis should be given to address the situation EnglishHyponatraemia, mortality, logistic regressionhttp://ijcrr.com/abstract.php?article_id=43http://ijcrr.com/article_html.php?did=43

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareTHE EFFECT OF REGULAR AEROBIC EXERCISE ON THE FBS, HOMA INDEXES AND LIPID PROFILES IN NON-ACTIVE OBESE MEN; WITH EMPHASIS ON RAMADAN FASTING English3138Bijeh NahidEnglish Abbasian SadeghEnglish Azimkhani AminEnglish Sajedi HeydarEnglishBackground: We designed this study to evaluate the effect of aerobic exercise and Ramadan fasting on plasma lipids profile and serum glucose among non-active obese men. So, purpose of the study was to survey the effect of regular aerobic exercise and Ramadan fasting on the on plasma lipids profile and serum glucose in non-active obese men. Methods: In this study, 18 obese men aged 50-40 with a BMI over 30 kg per square meter as a public call among the 70 subjects were selected randomly and after it were divided in to fasting (N=9) and fasting and exercise (N=9) groups. Then while the first group would do only fasting, fasting and exercise group in addition to the intervention fasting group, exercise to be carried out in 27 sessions. We evaluated blood glucose, triglycerides (TG), cholesterol, low-density lipoprotein (LDL-c), high-density lipoprotein (HDL-c), and Triglycerides at 7 day before, at week 2th and 4th of the Ramadan month and after two weeks after the end of Ramadan. Also, for check the desired changes in the month of Ramadan, blood samples were taken from four different times. Finally, using repeated measures analysis of variance in the level of p English regular aerobic exercise, Ramadan fasting, high-density lipoprotein (HDL-c) and obese man http://ijcrr.com/abstract.php?article_id=46http://ijcrr.com/article_html.php?did=46

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410307EnglishN2013March31HealthcareMEDITATION AND YOGA AS ALTERNATIVE THERAPY FOR PRIMARY DYSMENORRHEA English3944Usha NagEnglish Madhavi KodaliEnglishObjectives: The objective of the study is to analyze the effect of yoga and meditation as alternative therapy for primary dysmenorrhea in young students and its outcome on school absenteeism. Materials and Methods: 113 medical students, unmarried girls from Dr. Pinnamaneni Siddhartha Medical college with primary dysmenorrhoea were randomly assigned to study (n = 60) and control group (n = 53). Semi structured questionnaire and the Numerical rating scale for pain were administered on all the participants at baseline and after three months. The study group was subjected to yoga and pranayama and meditation. Data was analysed using Microsoft Excel and the results were expressed as proportions. Chi square test was applied to find out the significance of association and p value English absenteeism, dysmenorrhea, yogahttp://ijcrr.com/abstract.php?article_id=51http://ijcrr.com/article_html.php?did=51