Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410309EnglishN2013May25HealthcareMICROALBUMINURIA IN PREDIABETES GROUP IN RURAL GENERAL HOSPITAL English0107Anjaneya Prasad V.English Krishna Murthy V.English Pradeep Babu K.EnglishBackground: Development of target organ damage like chronic kidney disease and coronary artery disease in diabetes is more common and more rapid.Identifying sub clinical target organ damage in prediabetic phase is essential to prevent complications. Objective: Prediabetes is an elevation in serum fasting glucose level of:100 to 125 mg/dL (5.6 mM to 6.9 mM) and Glycated hemoglobin between 5.7 and 6.4 percent . The purpose of this case – control study was to corelate microalbuminuria to Prediabetes. Method: This study was done at the Department of Medicine and Department of Biochemistry, DR. PSIMS & RF foundation Chinaoutpally, A.P.India between July 2011 to Dec 2012. 500 patients (250 cases, 250 controls) above 18 years of age were included in the study. The microalbuminuric reference range was 30 – 300mg/day. Results: Microalbuminuria levels were found to be significantly higher in Prediabetes patients and in males when compared to female patients. Conclusions: Prediabetes patients with high mean microalbuminuria and high mean CRP levels with significant elevated lipid levels had developed significant complications. English Prediabetes, Microalbuminuria, C-Reactive Proteinhttp://ijcrr.com/abstract.php?article_id=13http://ijcrr.com/article_html.php?did=13

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410309EnglishN2013May25HealthcareA SINGLE ORAL HIGH DOSE TOXICITY STUDY OF KALANCHOE INTEGRA VAR. CRENATA (ANDR.) CUF LEAF EXTRACT IN ICR MICE: HISTOPATHOLOGICAL AND BIOCHEMICAL CHANGES English0817Antwi Daniel A.English Asiedu-Gyekye Isaac J.English Awortwe CharlesEnglish Adjei SamuelEnglish Addo PhyllisEnglishBackground of Study: The Kalanchoe genus is a succulent perennial plant belonging to the class Bryophyllum. It thrives at temperate areas of the world. In Africa, over 200 species have being identified and many of these species have been used medicinally especially Kalanchoe pinnata and Kalanchoe integra in Ghana for the treatment of various ailments. Aim/Objective: To evaluate the safety of the aqueous extract of the fresh leaves of K. integra during a single oral high dose of 5000 mg/kg b.wt in ICR mice, a study conducted by the fixed dose method. Research methodology: Freshly prepared aqueous leave extract were strained using muslin and freeze-dried, reconstituted and administered to ICR mice of either sex (21-25 g). The animals were kept under standard conditions and experimental procedure conducted in accordance with animal research guidelines. Blood samples for biochemical analysis were obtained by cardiac puncture. Gross and histopathological examinations were performed and statistical analysis was done using Graphpad Prism 5. Results: No deaths and slight weight increases (pEnglishKalanchoe, acute toxicity, histopathologyhttp://ijcrr.com/abstract.php?article_id=20http://ijcrr.com/article_html.php?did=20

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410309EnglishN2013May25HealthcareEVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF NYCTANTHES ARBOR-TRISTIS LEAVES English1625Chaitali PattanayakEnglish Pratyay Pratim DattaEnglish Anju PrasadEnglish Parbaty PandaEnglishEnglishNyctanthes arbor-tristis, anti-inflammatory, carrageenan.http://ijcrr.com/abstract.php?article_id=36http://ijcrr.com/article_html.php?did=36

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410309EnglishN2013May25HealthcareFREQUENCY AND DISTRIBUTION OF BLOOD GROUPS AMONG MEDICAL STUDENTS OF GREAT EASTERN MEDICAL SCHOOL, SRIKAKULAM, ANDHRAPRADESH, INDIA English2633G. G. SwamyEnglish B. ChandrasekharEnglish J. ParameswariEnglish S. MadhuravaniEnglishBackground of study: Apart from blood transfusion practice, knowing of the ABO and Rh blood groups are useful in population genetic studies, researching population migration patterns as well as resolving certain medico legal issues, particularly of disputed paternity cases and certain diseases. Objective: The present study aim is to determine the most commonblood groups for purpose of emergency blood transfusion and to comparewith other studies. Research Methodology: The observational cross sectional study was done at Department of Pathology at Great Eastern Medical School, Srikakulam, Andhrapradesh of South India during October 2012 to Februry 2013. Blood group of the Medical students was determined by commercially available standard monoclonal antisera .The sample blood was collected by finger prick method. A drop of monoclonal reagent anti A, anti B, and Anti D were added to a drop of blood on clean and fresh glass slides and mixed well with glass rod. Results of agglutination were recorded immediately. Results: During the observation, total number of subjects studied were175, among them 78 was males and 97 were females. Study showed Blood group O was more predominant in both males and Females. Conclusion : It was observed that in both male and females the most frequently occurring ABO blood group was O (46.9%), followed by B (29.7 %), A (17.1 %), and AB (5.1%). Rh positive seen in 94.9% of the students. Only 5.1 % of the students in our study group were Rh negative. EnglishBlood groups, emergency blood transfusion, ABO, Rh Typinghttp://ijcrr.com/abstract.php?article_id=44http://ijcrr.com/article_html.php?did=44

Radiance Research AcademyInternational Journal of Current Research and Review2231-21960975-52410309EnglishN2013May25HealthcareSTUDY OF CLINICAL PATTERN IN PATIENTS WITH CUTANEOUS ADVERSE DRUG REACTIONS English3439Balpande K.G.English Borkar A.S.English Badwaik R.T.EnglishIntroduction: Cutaneous adverse drug reactions (cutaneous ADRs) are most common and occur in up to 8% of the global general population and in 2-3% of hospitalized patients. Hence, the present study was undertaken to determine the clinical pattern of all cutaneous ADRs. It also emphasises on the need and importance of an effective pharmacovigilance programme. Objective: To assess the clinical pattern of cutaneous ADRs and to recognize offending drug. Method: This study was conducted in a 800 beded tertiary care hospital in central India. All patients who attended dermatology OPD were screened and patients with suspected cutaneous ADRs presented primarily or referred from other departments of the hospital during the study period were enrolled. The diagnosis of the cutaneous ADR was based on history of drug ingestion, clinical findings and exclusion of other simillar disorders and it was done by a consultant dermatologist. Results: From 1st January 2011 to 31st December 2011, 116 cases of cutaneous ADRs (64 males and 52 females) were reported. Urticaria/angioedema (32.75%) was the most frequent cutaneous ADR reported followed by maculopapular rash (27.58%), fixed drug eruption (20.68%) and photosensitivity (12.06%). Antimicrobial drugs (40.51%) were the most common offending group of drugs causing the cutaneous ADRs followed by analgesic/anti-inflammatory/antipyretics (32.75%) and antiepileptics (14.65%). Sulfonamides were the most common offending drug followed by ibuprofen among all individual drugs. Conclusion: Urticaria/angioedema was the most common cutaneous ADR seen. Sulphonamides were the most common offending agent causing cutaneous ADRs. Englishcutaneous adverse drug reactions, tertiary care hospitalhttp://ijcrr.com/abstract.php?article_id=49http://ijcrr.com/article_html.php?did=49